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TargetSerine/threonine-protein kinase TAO3
LigandBDBM50429615
Substrate/Competitorn/a
Meas. Tech.ChEMBL_2198933 (CHEMBL5111449)
IC50 45±n/a nM
Citation Drewry, DHPotjewyd, FMBayati, ASmith, JLDickmander, RJHowell, STaft-Benz, SMin, SMHossain, MAHeise, MMcPherson, PSMoorman, NJAxtman, AD Identification and Utilization of a Chemical Probe to Interrogate the Roles of PIKfyve in the Lifecycle of ?-Coronaviruses. J Med Chem65:12860-12882 (2022) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Serine/threonine-protein kinase TAO3
Name:Serine/threonine-protein kinase TAO3
Synonyms:DPK | JIK | KDS | MAP3K18 | TAOK3 | TAOK3_HUMAN
Type:PROTEIN
Mol. Mass.:105420.26
Organism:Homo sapiens (Human)
Description:ChEMBL_774581
Residue:898
Sequence:
MRKGVLKDPEIADLFYKDDPEELFIGLHEIGHGSFGAVYFATNAHTSEVVAIKKMSYSGK
QTHEKWQDILKEVKFLRQLKHPNTIEYKGCYLKEHTAWLVMEYCLGSASDLLEVHKKPLQ
EVEIAAITHGALHGLAYLHSHALIHRDIKAGNILLTEPGQVKLADFGSASMASPANSFVG
TPYWMAPEVILAMDEGQYDGKVDIWSLGITCIELAERKPPLFNMNAMSALYHIAQNDSPT
LQSNEWTDSFRRFVDYCLQKIPQERPTSAELLRHDFVRRDRPLRVLIDLIQRTKDAVREL
DNLQYRKMKKILFQETRNGPLNESQEDEEDSEHGTSLNREMDSLGSNHSIPSMSVSTGSQ
SSSVNSMQEVMDESSSELVMMHDDESTINSSSSVVHKKDHVFIRDEAGHGDPRPEPRPTQ
SVQSQALHYRNRERFATIKSASLVTRQIHEHEQENELREQMSGYKRMRRQHQKQLIALEN
KLKAEMDEHRLKLQKEVETHANNSSIELEKLAKKQVAIIEKEAKVAAADEKKFQQQILAQ
QKKDLTTFLESQKKQYKICKEKIKEEMNEDHSTPKKEKQERISKHKENLQHTQAEEEAHL
LTQQRLYYDKNCRFFKRKIMIKRHEVEQQNIREELNKKRTQKEMEHAMLIRHDESTRELE
YRQLHTLQKLRMDLIRLQHQTELENQLEYNKRRERELHRKHVMELRQQPKNLKAMEMQIK
KQFQDTCKVQTKQYKALKNHQLEVTPKNEHKTILKTLKDEQTRKLAILAEQYEQSINEMM
ASQALRLDEAQEAECQALRLQLQQEMELLNAYQSKIKMQTEAQHERELQKLEQRVSLRRA
HLEQKIEEELAALQKERSERIKNLLERQEREIETFDMESLRMGFGNLVTLDFPKEDYR
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50429615
n/a
NameBDBM50429615
Synonyms:CHEMBL2334586
TypeSmall organic molecule
Emp. Form.C20H20N4O
Mol. Mass.332.399
SMILESCC(C)(O)C#Cc1ccc2[nH]c3CCCc4cnc(N)nc4-c3c2c1
Structure
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