| Reaction Details |
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 | Report a problem with these data |
| Target | Cyclin-dependent kinase-like 4 |
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| Ligand | BDBM50591066 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2199079 (CHEMBL5111595) |
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| IC50 | 118±n/a nM |
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| Citation |  Jackson, JJ; Shibuya, GM; Ravishankar, B; Adusumilli, L; Bradford, D; Brockstedt, DG; Bucher, C; Bui, M; Cho, C; Colas, C; Cutler, G; Dukes, A; Han, X; Hu, DX; Jacobson, S; Kassner, PD; Katibah, GE; Ko, MYM; Kolhatkar, U; Leger, PR; Ma, A; Marshall, L; Maung, J; Ng, AA; Okano, A; Pookot, D; Poon, D; Ramana, C; Reilly, MK; Robles, O; Schwarz, JB; Shakhmin, AA; Shunatona, HP; Sreenivasan, R; Tivitmahaisoon, P; Xu, M; Zaw, T; Wustrow, DJ; Zibinsky, M Potent GCN2 Inhibitor Capable of Reversing MDSC-Driven T Cell Suppression Demonstrates In Vivo Efficacy as a Single Agent and in Combination with Anti-Angiogenesis Therapy. J Med Chem65:12895-12924 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cyclin-dependent kinase-like 4 |
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| Name: | Cyclin-dependent kinase-like 4 |
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| Synonyms: | 2.7.11.22 | CDKL4 | CDKL4_HUMAN | Cyclin-dependent kinase-like 4 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 43397.80 |
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| Organism: | Homo sapiens |
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| Description: | ChEMBL_119076 |
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| Residue: | 379 |
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| Sequence: | MEKYEKLAKTGEGSYGVVFKCRNKTSGQVVAVKKFVESEDDPVVKKIALREIRMLKQLKH
PNLVNLIEVFRRKRKMHLVFEYCDHTLLNELERNPNGVADGVIKSVLWQTLQALNFCHIH
NCIHRDIKPENILITKQGIIKICDFGFAQILIPGDAYTDYVATRWYRAPELLVGDTQYGS
SVDIWAIGCVFAELLTGQPLWPGKSDVDQLYLIIRTLGKLIPRHQSIFKSNGFFHGISIP
EPEDMETLEEKFSDVHPVALNFMKGCLKMNPDDRLTCSQLLESSYFDSFQEAQIKRKARN
EGRNRRRQQQAPKSAFPRLFLKTKICQVQRNETQTSGNQILPNGPILQNSMVTVMTNINS
AVYQVTVLHLLSENFEVKS
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| BDBM50591066 |
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| n/a |
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| Name | BDBM50591066 |
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| Synonyms: | CHEMBL5190023 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H23BrN8OS |
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| Mol. Mass. | 527.44 |
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| SMILES | CNC(=O)[C@]1(C)CC[C@H](C1)Nc1ncc2c(Br)nn(-c3ccc(cc3)-c3nnc(C)s3)c2n1 |r| |
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| Structure | 
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