| Reaction Details |
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 | Report a problem with these data |
| Target | Galectin-3 |
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| Ligand | BDBM50591134 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2199430 (CHEMBL5111946) |
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| Kd | 3.0±n/a nM |
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| Citation |  Zetterberg, FR; MacKinnon, A; Brimert, T; Gravelle, L; Johnsson, RE; Kahl-Knutson, B; Leffler, H; Nilsson, UJ; Pedersen, A; Peterson, K; Roper, JA; Schambye, H; Slack, RJ; Tantawi, S Discovery and Optimization of the First Highly Effective and Orally Available Galectin-3 Inhibitors for Treatment of Fibrotic Disease. J Med Chem65:12626-12638 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Galectin-3 |
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| Name: | Galectin-3 |
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| Synonyms: | LEG3_HUMAN | LGALS3 | MAC2 |
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| Type: | Enzyme |
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| Mol. Mass.: | 26156.54 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P17931 |
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| Residue: | 250 |
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| Sequence: | MADNFSLHDALSGSGNPNPQGWPGAWGNQPAGAGGYPGASYPGAYPGQAPPGAYPGQAPP
GAYPGAPGAYPGAPAPGVYPGPPSGPGAYPSSGQPSATGAYPATGPYGAPAGPLIVPYNL
PLPGGVVPRMLITILGTVKPNANRIALDFQRGNDVAFHFNPRFNENNRRVIVCNTKLDNN
WGREERQSVFPFESGKPFKIQVLVEPDHFKVAVNDAHLLQYNHRVKKLNEISKLGISGDI
DLTSASYTMI
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| BDBM50591134 |
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| n/a |
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| Name | BDBM50591134 |
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| Synonyms: | CHEMBL5181494 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H30F2N6O7S |
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| Mol. Mass. | 632.636 |
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| SMILES | [H][C@]1(O[C@H](C)[C@H](O)[C@@H]([C@H]1O)n1cc(nn1)-c1cccc(F)c1)S[C@@H]1O[C@H](CO)[C@H](O)[C@@H]([C@H]1O)n1cc(nn1)-c1cccc(F)c1 |r| |
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| Structure | 
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