Reaction Details |
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Target | Histone deacetylase 8 |
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Ligand | BDBM50591851 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_2202278 (CHEMBL5114986) |
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IC50 | 113±n/a nM |
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Citation | Federico, S; Khan, T; Fontana, A; Brogi, S; Benedetti, R; Sarno, F; Carullo, G; Pezzotta, A; Saraswati, AP; Passaro, E; Pozzetti, L; Papa, A; Relitti, N; Gemma, S; Butini, S; Pistocchi, A; Ramunno, A; Vincenzi, F; Varani, K; Tatangelo, V; Patrussi, L; Baldari, CT; Saponara, S; Gorelli, B; Lamponi, S; Valoti, M; Saccoccia, F; Giannaccari, M; Ruberti, G; Herp, D; Jung, M; Altucci, L; Campiani, G Azetidin-2-one-based small molecules as dual hHDAC6/HDAC8 inhibitors: Investigation of their mechanism of action and impact of dual inhibition profile on cell viability. Eur J Med Chem238:0 (2022) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Histone deacetylase 8 |
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Name: | Histone deacetylase 8 |
Synonyms: | HD8 | HDAC8 | HDAC8_HUMAN | HDACL1 | Histone deacetylase 8 (HDAC-8) | Human HDAC8 |
Type: | Enzyme |
Mol. Mass.: | 41749.60 |
Organism: | Homo sapiens (Human) |
Description: | Q9BY41 |
Residue: | 377 |
Sequence: | MEEPEEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPK
VASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATI
TAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLH
HGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKY
YQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLI
LGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPH
RIQQILNYIKGNLKHVV
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BDBM50591851 |
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n/a |
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Name | BDBM50591851 |
Synonyms: | CHEMBL5189806 |
Type | Small organic molecule |
Emp. Form. | C29H29N3O4 |
Mol. Mass. | 483.5583 |
SMILES | ONC(=O)c1ccc(CC(=O)N2CCC(CC2)N2CC(C2=O)(c2ccccc2)c2ccccc2)cc1 |
Structure |
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