| Reaction Details |
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 | Report a problem with these data |
| Target | RNA demethylase ALKBH5 |
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| Ligand | BDBM50592109 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2203174 (CHEMBL5115882) |
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| IC50 | 2734±n/a nM |
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| Citation |  Fang, Z; Mu, B; Liu, Y; Guo, N; Xiong, L; Guo, Y; Xia, A; Zhang, R; Zhang, H; Yao, R; Fan, Y; Li, L; Yang, S; Xiang, R Discovery of a potent, selective and cell active inhibitor of m Eur J Med Chem238:0 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| RNA demethylase ALKBH5 |
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| Name: | RNA demethylase ALKBH5 |
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| Synonyms: | 1.14.11.53 | ABH5 | ALKB5_HUMAN | ALKBH5 | Alkylated DNA repair protein alkB homolog 5 | Alpha-ketoglutarate-dependent dioxygenase alkB homolog 5 | OFOXD1 | RNA demethylase ALKBH5 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 44270.53 |
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| Organism: | Homo sapiens |
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| Description: | ChEMBL_109901 |
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| Residue: | 394 |
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| Sequence: | MAAASGYTDLREKLKSMTSRDNYKAGSREAAAAAAAAVAAAAAAAAAAEPYPVSGAKRKY
QEDSDPERSDYEEQQLQKEEEARKVKSGIRQMRLFSQDECAKIEARIDEVVSRAEKGLYN
EHTVDRAPLRNKYFFGEGYTYGAQLQKRGPGQERLYPPGDVDEIPEWVHQLVIQKLVEHR
VIPEGFVNSAVINDYQPGGCIVSHVDPIHIFERPIVSVSFFSDSALCFGCKFQFKPIRVS
EPVLSLPVRRGSVTVLSGYAADEITHCIRPQDIKERRAVIILRKTRLDAPRLETKSLSSS
VLPPSYASDRLSGNNRDPALKPKRSHRKADPDAAHRPRILEMDKEENRRSVLLPTHRRRG
SFSSENYWRKSYESSEDCSEAAGSPARKVKMRRH
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| BDBM50592109 |
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| n/a |
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| Name | BDBM50592109 |
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| Synonyms: | CHEMBL5195733 |
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| Type | Small organic molecule |
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| Emp. Form. | C10H7ClN2O3 |
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| Mol. Mass. | 238.627 |
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| SMILES | OC(=O)c1cc(O)n(n1)-c1ccc(Cl)cc1 |
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| Structure | 
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