| Reaction Details |
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 | Report a problem with these data |
| Target | Transient receptor potential cation channel subfamily M member 8 |
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| Ligand | BDBM50592154 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2203211 (CHEMBL5115919) |
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| IC50 | 2200±n/a nM |
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| Citation |  Di Sarno, V; Giovannelli, P; Medina-Peris, A; Ciaglia, T; Di Donato, M; Musella, S; Lauro, G; Vestuto, V; Smaldone, G; Di Matteo, F; Bifulco, G; Castoria, G; Migliaccio, A; Fernandez-Carvajal, A; Campiglia, P; Gomez-Monterrey, I; Ostacolo, C; Bertamino, A New TRPM8 blockers exert anticancer activity over castration-resistant prostate cancer models. Eur J Med Chem238:0 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Transient receptor potential cation channel subfamily M member 8 |
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| Name: | Transient receptor potential cation channel subfamily M member 8 |
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| Synonyms: | Cmr1 | TRPM8_RAT | Transient receptor potential M8 protein (TRPM8) | Transient receptor potential cation channel subfamily M member 8 | Trpm8 |
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| Type: | Enzyme |
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| Mol. Mass.: | 127633.53 |
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| Organism: | Rattus norvegicus (Rat) |
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| Description: | Q8R455 |
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| Residue: | 1104 |
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| Sequence: | MSFEGARLSMRSRRNGTLGSTRTLYSSVSRSTDVSYSESDLVNFIQANFKKRECVFFTRD
SKAMESICKCGYAQSQHIEGTQINQNEKWNYKKHTKEFPTDAFGDIQFETLGKKGKYLRL
SCDTDSETLYELLTQHWHLKTPNLVISVTGGAKNFALKPRMRKIFSRLIYIAQSKGAWIL
TGGTHYGLMKYIGEVVRDNTISRNSEENIVAIGIAAWGMVSNRDTLIRNCDDEGHFSAQY
IMDDFMRDPLYILDNNHTHLLLVDNGCHGHPTVEAKLRNQLEKYISERTSQDSNYGGKIP
IVCFAQGGGRETLKAINTSVKSKIPCVVVEGSGQIADVIASLVEVEDVLTSSMVKEKLVR
FLPRTVSRLPEEEIESWIKWLKEILESPHLLTVIKMEEAGDEVVSSAISYALYKAFSTNE
QDKDNWNGQLKLLLEWNQLDLASDEIFTNDRRWESADLQEVMFTALIKDRPKFVRLFLEN
GLNLQKFLTNEVLTELFSTHFSTLVYRNLQIAKNSYNDALLTFVWKLVANFRRSFWKEDR
SSREDLDVELHDASLTTRHPLQALFIWAILQNKKELSKVIWEQTKGCTLAALGASKLLKT
LAKVKNDINAAGESEELANEYETRAVELFTECYSSDEDLAEQLLVYSCEAWGGSNCLELA
VEATDQHFIAQPGVQNFLSKQWYGEISRDTKNWKIILCLFIIPLVGCGLVSFRKKPIDKH
KKLLWYYVAFFTSPFVVFSWNVVFYIAFLLLFAYVLLMDFHSVPHTPELILYALVFVLFC
DEVRQWYMNGVNYFTDLWNVMDTLGLFYFIAGIVFRLHSSNKSSLYSGRVIFCLDYIIFT
LRLIHIFTVSRNLGPKIIMLQRMLIDVFFFLFLFAVWMVAFGVARQGILRQNEQRWRWIF
RSVIYEPYLAMFGQVPSDVDSTTYDFSHCTFSGNESKPLCVELDEYNLPRFPEWITIPLV
CIYMLSTNILLVNLLVAMFGYTVGIVQENNDQVWKFQRYFLVQEYCNRLNIPFPFVVFAY
FYMVVKKCFKCCCKEKNTESSACCFRNEDNETLAWEGVMKENYLVKINTKANDNAEEMRH
RFRQLDTKLNDLKGLLKEIANKIK
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| BDBM50592154 |
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| n/a |
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| Name | BDBM50592154 |
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| Synonyms: | CHEMBL5173566 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H18F2N2O4 |
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| Mol. Mass. | 436.4075 |
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| SMILES | [H][C@]12Cc3cc(O)c(O)cc3[C@@H](N1C(=O)N(Cc1ccc(F)cc1)C2=O)c1ccc(F)cc1 |r| |
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| Structure | 
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