Reaction Details |
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Target | Prothrombin |
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Ligand | BDBM50592216 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_2203369 (CHEMBL5116077) |
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Ki | 42±n/a nM |
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Citation | Pilgram, O; Keils, A; Benary, GE; Müller, J; Merkl, S; Ngaha, S; Huber, S; Chevillard, F; Harbig, A; Magdolen, V; Heine, A; Böttcher-Friebertshäuser, E; Steinmetzer, T Improving the selectivity of 3-amidinophenylalanine-derived matriptase inhibitors. Eur J Med Chem238:0 (2022) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Prothrombin |
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Name: | Prothrombin |
Synonyms: | Activation peptide fragment 1 | Activation peptide fragment 2 | Coagulation factor II | F2 | Prothrombin | THRB_BOVIN | Thrombin | Thrombin heavy chain | Thrombin light chain |
Type: | Enzyme |
Mol. Mass.: | 70502.73 |
Organism: | Bos taurus (Bovine) |
Description: | P00735 |
Residue: | 625 |
Sequence: | MARVRGPRLPGCLALAALFSLVHSQHVFLAHQQASSLLQRARRANKGFLEEVRKGNLERE
CLEEPCSREEAFEALESLSATDAFWAKYTACESARNPREKLNECLEGNCAEGVGMNYRGN
VSVTRSGIECQLWRSRYPHKPEINSTTHPGADLRENFCRNPDGSITGPWCYTTSPTLRRE
ECSVPVCGQDRVTVEVIPRSGGSTTSQSPLLETCVPDRGREYRGRLAVTTSGSRCLAWSS
EQAKALSKDQDFNPAVPLAENFCRNPDGDEEGAWCYVADQPGDFEYCDLNYCEEPVDGDL
GDRLGEDPDPDAAIEGRTSEDHFQPFFNEKTFGAGEADCGLRPLFEKKQVQDQTEKELFE
SYIEGRIVEGQDAEVGLSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNF
TVDDLLVRIGKHSRTRYERKVEKISMLDKIYIHPRYNWKENLDRDIALLKLKRPIELSDY
IHPVCLPDKQTAAKLLHAGFKGRVTGWGNRRETWTTSVAEVQPSVLQVVNLPLVERPVCK
ASTRIRITDNMFCAGYKPGEGKRGDACEGDSGGPFVMKSPYNNRWYQMGIVSWGEGCDRD
GKYGFYTHVFRLKKWIQKVIDRLGS
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BDBM50592216 |
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n/a |
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Name | BDBM50592216 |
Synonyms: | CHEMBL5180406 |
Type | Small organic molecule |
Emp. Form. | C33H41N5O6S |
Mol. Mass. | 635.774 |
SMILES | COc1ccc(c(OC)c1)-c1cccc(c1)S(=O)(=O)N[C@@H](Cc1cccc(c1)C(N)=N)C(=O)N1CCN(CC1)C(=O)C(C)(C)C |r| |
Structure |
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