Ki Summary

Reaction Details

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Target

Melanocortin receptor 4

Ligand

BDBM50592982

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_2206711 (CHEMBL5119419)

8.13±n/a nM

Citation

Reynaud, S; Laurin, SA; Ciolek, J; Barbe, P; Van Baelen, AC; Susset, M; Blondel, F; Ghazarian, M; Boeri, J; Vanden Driessche, M; Upert, G; Mourier, G; Kessler, P; Konnert, L; Beroud, R; Keck, M; Servent, D; Bouvier, M; Gilles, N From a Cone Snail Toxin to a Competitive MC4R Antagonist. J Med Chem65:12084-12094 (2022) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Melanocortin receptor 4

Name:

Melanocortin receptor 4

Synonyms:

Type:

Enzyme

Mol. Mass.:

36949.50

Organism:

Homo sapiens (Human)

Description:

P32245

Residue:

332

Sequence:

MVNSTHRGMHTSLHLWNRSSYRLHSNASESLGKGYSDGGCYEQLFVSPEVFVTLGVISLL
ENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVN
IDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGIIISCIWAACTVS
GILFIIYSDSSAVIICLITMFFTMLALMASLYVHMFLMARLHIKRIAVLPGTGAIRQGAN
MKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPL
IYALRSQELRKTFKEIICCYPLGGLCDLSSRY

BDBM50592982

n/a

Name

BDBM50592982

Synonyms:

CHEMBL5176092

Type

Small organic molecule

Emp. Form.

C148H223N41O31

Mol. Mass.

3072.6103

SMILES

CC(C)C[C@H](N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(N)=O |r|

Structure