| Reaction Details |
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 | Report a problem with these data |
| Target | Cyclin-dependent kinase 8 |
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| Ligand | BDBM50593066 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2206878 (CHEMBL5119586) |
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| IC50 | 65±n/a nM |
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| Citation |  Zhang, XX; Xiao, Y; Yan, YY; Wang, YM; Jiang, H; Wu, L; Shi, JB; Liu, XH Discovery of the Novel 1 J Med Chem65:12095-12123 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cyclin-dependent kinase 8 |
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| Name: | Cyclin-dependent kinase 8 |
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| Synonyms: | CDK8 | CDK8_HUMAN | Cell division protein kinase 8 | Cyclin-Dependent Kinase 8 (CDK8) | Mediator complex subunit CDK8 | Mediator of RNA polymerase II transcription subunit CDK8 | Protein kinase K35 |
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| Type: | Serine/threonine-protein kinase |
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| Mol. Mass.: | 53300.21 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P49336 |
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| Residue: | 464 |
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| Sequence: | MDYDFKVKLSSERERVEDLFEYEGCKVGRGTYGHVYKAKRKDGKDDKDYALKQIEGTGIS
MSACREIALLRELKHPNVISLQKVFLSHADRKVWLLFDYAEHDLWHIIKFHRASKANKKP
VQLPRGMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLF
NSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQED
IKTSNPYHHDQLDRIFNVMGFPADKDWEDIKKMPEHSTLMKDFRRNTYTNCSLIKYMEKH
KVKPDSKAFHLLQKLLTMDPIKRITSEQAMQDPYFLEDPLPTSDVFAGCQIPYPKREFLT
EEEPDDKGDKKNQQQQQGNNHTNGTGHPGNQDSSHTQGPPLKKVRVVPPTTTSGGLIMTS
DYQRSNPHAAYPNPGPSTSQPQSSMGYSATSQQPPQYSHQTHRY
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| BDBM50593066 |
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| n/a |
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| Name | BDBM50593066 |
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| Synonyms: | CHEMBL5203621 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H30F3N5O2 |
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| Mol. Mass. | 537.576 |
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| SMILES | FC(F)(F)c1cc(NC(=O)CCc2cccc(c2)-c2cnc3[nH]ccc3c2)ccc1NCCN1CCOCC1 |
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| Structure | 
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