| Reaction Details |
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 | Report a problem with these data |
| Target | Choline kinase alpha |
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| Ligand | BDBM50054103 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_305138 (CHEMBL832433) |
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| IC50 | 81100.0±n/a nM |
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| Citation |  Sánchez-Martín, R; Campos, JM; Conejo-García, A; Cruz-López, O; Báñez-Coronel, M; Rodríguez-González, A; Gallo, MA; Lacal, JC; Espinosa, A Symmetrical bis-quinolinium compounds: new human choline kinase inhibitors with antiproliferative activity against the HT-29 cell line. J Med Chem48:3354-63 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Choline kinase alpha |
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| Name: | Choline kinase alpha |
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| Synonyms: | CHK | CHKA | CHKA_HUMAN | CKI | Choline kinase alpha |
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| Type: | PROTEIN |
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| Mol. Mass.: | 52248.44 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1290064 |
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| Residue: | 457 |
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| Sequence: | MKTKFCTGGEAEPSPLGLLLSCGSGSAAPAPGVGQQRDAASDLESKQLGGQQPPLALPPP
PPLPLPLPLPQPPPPQPPADEQPEPRTRRRAYLWCKEFLPGAWRGLREDEFHISVIRGGL
SNMLFQCSLPDTTATLGDEPRKVLLRLYGAILQMRSCNKEGSEQAQKENEFQGAEAMVLE
SVMFAILAERSLGPKLYGIFPQGRLEQFIPSRRLDTEELSLPDISAEIAEKMATFHGMKM
PFNKEPKWLFGTMEKYLKEVLRIKFTEESRIKKLHKLLSYNLPLELENLRSLLESTPSPV
VFCHNDCQEGNILLLEGRENSEKQKLMLIDFEYSSYNYRGFDIGNHFCEWMYDYSYEKYP
FFRANIRKYPTKKQQLHFISSYLPAFQNDFENLSTEEKSIIKEEMLLEVNRFALASHFLW
GLWSIVQAKISSIEFGYMDYAQARFDAYFHQKRKLGV
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| BDBM50054103 |
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| n/a |
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| Name | BDBM50054103 |
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| Synonyms: | 1,1'-[biphenyl-4,4'-diylbis(methylene)]-bis(4-aminoquinolinium) | 1-{4-[4-(4-amino-1-quinoliniumylmethyl)phenyl]benzyl}-4-quinoliniumamine | CHEMBL269729 | CHEMBL370040 |
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| Type | Small organic molecule |
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| Emp. Form. | C32H28N4 |
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| Mol. Mass. | 468.5904 |
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| SMILES | [NH2+]=c1ccn(Cc2ccc(cc2)-c2ccc(Cn3ccc(=[NH2+])c4ccccc34)cc2)c2ccccc12 |
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| Structure | 
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