| Reaction Details |
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 | Report a problem with these data |
| Target | G protein-activated inward rectifier potassium channel 1 |
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| Ligand | BDBM50593395 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2208081 (CHEMBL5121030) |
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| EC50 | 1400±n/a nM |
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| Citation |  Sharma, S; Lesiak, L; Aretz, CD; Du, Y; Kumar, S; Gautam, N; Alnouti, Y; Dhuria, NV; Chhonker, YS; Weaver, CD; Hopkins, CR Discovery, synthesis and biological characterization of a series of RSC Med Chem12:1366-1373 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| G protein-activated inward rectifier potassium channel 1 |
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| Name: | G protein-activated inward rectifier potassium channel 1 |
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| Synonyms: | GIRK-1 | GIRK1 | Inward rectifier K(+) channel Kir3.1 | KCNJ3 | KCNJ3_HUMAN | Potassium channel, inwardly rectifying subfamily J member 3 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 56610.74 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_107915 |
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| Residue: | 501 |
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| Sequence: | MSALRRKFGDDYQVVTTSSSGSGLQPQGPGQDPQQQLVPKKKRQRFVDKNGRCNVQHGNL
GSETSRYLSDLFTTLVDLKWRWNLFIFILTYTVAWLFMASMWWVIAYTRGDLNKAHVGNY
TPCVANVYNFPSAFLFFIETEATIGYGYRYITDKCPEGIILFLFQSILGSIVDAFLIGCM
FIKMSQPKKRAETLMFSEHAVISMRDGKLTLMFRVGNLRNSHMVSAQIRCKLLKSRQTPE
GEFLPLDQLELDVGFSTGADQLFLVSPLTICHVIDAKSPFYDLSQRSMQTEQFEIVVILE
GIVETTGMTCQARTSYTEDEVLWGHRFFPVISLEEGFFKVDYSQFHATFEVPTPPYSVKE
QEEMLLMSSPLIAPAITNSKERHNSVECLDGLDDITTKLPSKLQKITGREDFPKKLLRMS
STTSEKAYSLGDLPMKLQRISSVPGNSEEKLVSKTTKMLSDPMSQSVADLPPKLQKMAGG
AARMEGNLPAKLRKMNSDRFT
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| BDBM50593395 |
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| n/a |
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| Name | BDBM50593395 |
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| Synonyms: | CHEMBL5185110 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H21Cl2N3O4S |
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| Mol. Mass. | 458.359 |
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| SMILES | Clc1ccc(OCC(=O)Nc2cc(nn2C2CCS(=O)(=O)C2)C2CCC2)c(Cl)c1 |
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| Structure | 
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