Reaction Details |
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Target | Activin receptor type-1 |
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Ligand | BDBM50593553 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_2209044 (CHEMBL5121993) |
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IC50 | 210±n/a nM |
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Citation | Ullrich, T; Arista, L; Weiler, S; Teixeira-Fouchard, S; Broennimann, V; Stiefl, N; Head, V; Kramer, I; Guth, S Discovery of a novel 2-aminopyrazine-3-carboxamide as a potent and selective inhibitor of Activin Receptor-Like Kinase-2 (ALK2) for the treatment of fibrodysplasia ossificans progressiva. Bioorg Med Chem Lett64:0 (2022) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Activin receptor type-1 |
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Name: | Activin receptor type-1 |
Synonyms: | 2.7.11.30 | ACTR-I | ACVR1 | ACVR1_HUMAN | ACVRLK2 | ALK-2 | ALK2/ACVR1 | Activin receptor type I | Activin receptor-like kinase 2 | Activin receptor-like kinase 2 (ALK-2) | Activin receptor-like kinase 2 (ALK2/ACVR1) | Q04771 | SKR1 | Serine/threonine-protein kinase receptor R1 | TGF-B superfamily receptor type I | TSR-I |
Type: | n/a |
Mol. Mass.: | 57158.32 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 509 |
Sequence: | MVDGVMILPVLIMIALPSPSMEDEKPKVNPKLYMCVCEGLSCGNEDHCEGQQCFSSLSIN
DGFHVYQKGCFQVYEQGKMTCKTPPSPGQAVECCQGDWCNRNITAQLPTKGKSFPGTQNF
HLEVGLIILSVVFAVCLLACLLGVALRKFKRRNQERLNPRDVEYGTIEGLITTNVGDSTL
ADLLDHSCTSGSGSGLPFLVQRTVARQITLLECVGKGRYGEVWRGSWQGENVAVKIFSSR
DEKSWFRETELYNTVMLRHENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTL
DTVSCLRIVLSIASGLAHLHIEIFGTQGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVM
HSQSTNQLDVGNNPRVGTKRYMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEVARRMVS
NGIVEDYKPPFYDVVPNDPSFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQ
NPSARLTALRIKKTLTKIDNSLDKLKTDC
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BDBM50593553 |
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n/a |
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Name | BDBM50593553 |
Synonyms: | CHEMBL5178109 |
Type | Small organic molecule |
Emp. Form. | C20H26F3N5O2 |
Mol. Mass. | 425.4479 |
SMILES | CCN(CC)Cc1ccc(cc1)-c1cnc(N)c(n1)C(=O)NC[C@@](C)(O)C(F)(F)F |r| |
Structure |
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