| Reaction Details |
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 | Report a problem with these data |
| Target | Glutaminase kidney isoform, mitochondrial |
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| Ligand | BDBM109086 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2209091 (CHEMBL5122040) |
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| IC50 | 310±n/a nM |
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| Citation |  Carbone, D; Vestuto, V; Ferraro, MR; Ciaglia, T; Pecoraro, C; Sommella, E; Cascioferro, S; Salviati, E; Novi, S; Tecce, MF; Amodio, G; Iraci, N; Cirrincione, G; Campiglia, P; Diana, P; Bertamino, A; Parrino, B; Ostacolo, C Metabolomics-assisted discovery of a new anticancer GLS-1 inhibitor chemotype from a nortopsentin-inspired library: From phenotype screening to target identification. Eur J Med Chem234:0 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Glutaminase kidney isoform, mitochondrial |
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| Name: | Glutaminase kidney isoform, mitochondrial |
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| Synonyms: | GLS | GLS1 | GLSK_HUMAN | Glutaminase 1 | K-glutaminase | KIAA0838 | L-glutamine amidohydrolase |
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| Type: | Protein |
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| Mol. Mass.: | 73471.89 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O94925 |
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| Residue: | 669 |
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| Sequence: | MMRLRGSGMLRDLLLRSPAGVSATLRRAQPLVTLCRRPRGGGRPAAGPAAAARLHPWWGG
GGWPAEPLARGLSSSPSEILQELGKGSTHPQPGVSPPAAPAAPGPKDGPGETDAFGNSEG
KELVASGENKIKQGLLPSLEDLLFYTIAEGQEKIPVHKFITALKSTGLRTSDPRLKECMD
MLRLTLQTTSDGVMLDKDLFKKCVQSNIVLLTQAFRRKFVIPDFMSFTSHIDELYESAKK
QSGGKVADYIPQLAKFSPDLWGVSVCTVDGQRHSTGDTKVPFCLQSCVKPLKYAIAVNDL
GTEYVHRYVGKEPSGLRFNKLFLNEDDKPHNPMVNAGAIVVTSLIKQGVNNAEKFDYVMQ
FLNKMAGNEYVGFSNATFQSERESGDRNFAIGYYLKEKKCFPEGTDMVGILDFYFQLCSI
EVTCESASVMAATLANGGFCPITGERVLSPEAVRNTLSLMHSCGMYDFSGQFAFHVGLPA
KSGVAGGILLVVPNVMGMMCWSPPLDKMGNSVKGIHFCHDLVSLCNFHNYDNLRHFAKKL
DPRREGGDQRVKSVINLLFAAYTGDVSALRRFALSAMDMEQRDYDSRTALHVAAAEGHVE
VVKFLLEACKVNPFPKDRWNNTPMDEALHFGHHDVFKILQEYQVQYTPQGDSDNGKENQT
VHKNLDGLL
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| BDBM109086 |
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| n/a |
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| Name | BDBM109086 |
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| Synonyms: | US10793535, Cmpd ID 727 | US8604016, 670 | US9938267, Cmpd ID 670 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H24F3N7O3S |
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| Mol. Mass. | 571.574 |
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| SMILES | FC(F)(F)Oc1cccc(CC(=O)Nc2ccc(CCCCc3nnc(NC(=O)Cc4ccccn4)s3)nn2)c1 |
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| Structure | 
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