| Reaction Details |
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 | Report a problem with these data |
| Target | Glutaminase liver isoform, mitochondrial |
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| Ligand | BDBM50593582 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2209098 (CHEMBL5122047) |
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| EC50 | 12900±n/a nM |
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| Citation |  Carbone, D; Vestuto, V; Ferraro, MR; Ciaglia, T; Pecoraro, C; Sommella, E; Cascioferro, S; Salviati, E; Novi, S; Tecce, MF; Amodio, G; Iraci, N; Cirrincione, G; Campiglia, P; Diana, P; Bertamino, A; Parrino, B; Ostacolo, C Metabolomics-assisted discovery of a new anticancer GLS-1 inhibitor chemotype from a nortopsentin-inspired library: From phenotype screening to target identification. Eur J Med Chem234:0 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Glutaminase liver isoform, mitochondrial |
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| Name: | Glutaminase liver isoform, mitochondrial |
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| Synonyms: | 3.5.1.2 | GA | GLS | GLS2 | GLSL_HUMAN | Glutaminase liver isoform, mitochondrial | L-glutaminase | L-glutamine amidohydrolase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 66331.64 |
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| Organism: | Homo sapiens |
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| Description: | ChEMBL_117753 |
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| Residue: | 602 |
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| Sequence: | MRSMKALQKALSRAGSHCGRGGWGHPSRSPLLGGGVRHHLSEAAAQGRETPHSHQPQHQD
HDSSESGMLSRLGDLLFYTIAEGQERIPIHKFTTALKATGLQTSDPRLRDCMSEMHRVVQ
ESSSGGLLDRDLFRKCVSSNIVLLTQAFRKKFVIPDFEEFTGHVDRIFEDVKELTGGKVA
AYIPQLAKSNPDLWGVSLCTVDGQRHSVGHTKIPFCLQSCVKPLTYAISISTLGTDYVHK
FVGKEPSGLRYNKLSLNEEGIPHNPMVNAGAIVVSSLIKMDCNKAEKFDFVLQYLNKMAG
NEYMGFSNATFQSEKETGDRNYAIGYYLKEKKCFPKGVDMMAALDLYFQLCSVEVTCESG
SVMAATLANGGICPITGESVLSAEAVRNTLSLMHSCGMYDFSGQFAFHVGLPAKSAVSGA
ILLVVPNVMGMMCLSPPLDKLGNSHRGTSFCQKLVSLFNFHNYDNLRHCARKLDPRREGA
EIRNKTVVNLLFAAYSGDVSALRRFALSAMDMEQKDYDSRTALHVAAAEGHIEVVKFLIE
ACKVNPFAKDRWGNIPLDDAVQFNHLEVVKLLQDYQDSYTLSETQAEAAAEALSKENLES
MV
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| BDBM50593582 |
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| n/a |
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| Name | BDBM50593582 |
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| Synonyms: | CHEMBL5179292 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H27BrFN5OS |
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| Mol. Mass. | 556.493 |
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| SMILES | Br.Fc1ccc2n(CCCCN3CCOCC3)cc(-c3nc(cs3)-c3c[nH]c4ncccc34)c2c1 |
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| Structure | 
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