| Reaction Details |
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 | Report a problem with these data |
| Target | Protein mono-ADP-ribosyltransferase PARP11 |
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| Ligand | BDBM50594012 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2210626 (CHEMBL5123575) |
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| IC50 | 14±n/a nM |
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| Citation |  Nizi, MG; Maksimainen, MM; Murthy, S; Massari, S; Alaviuhkola, J; Lippok, BE; Sowa, ST; Galera-Prat, A; Prunskaite-Hyyryläinen, R; Lüscher, B; Korn, P; Lehtiö, L; Tabarrini, O Potent 2,3-dihydrophthalazine-1,4-dione derivatives as dual inhibitors for mono-ADP-ribosyltransferases PARP10 and PARP15. Eur J Med Chem237:0 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Protein mono-ADP-ribosyltransferase PARP11 |
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| Name: | Protein mono-ADP-ribosyltransferase PARP11 |
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| Synonyms: | 2.4.2.30 | ADP-ribosyltransferase diphtheria toxin-like 11 | ARTD11 | C12orf6 | PAR11_HUMAN | PARP-11 | PARP11 | Poly [ADP-ribose] polymerase 11 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 39601.40 |
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| Organism: | Homo sapiens |
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| Description: | ChEMBL_107591 |
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| Residue: | 338 |
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| Sequence: | MWEANPEMFHKAEELFSKTTNNEVDDMDTSDTQWGWFYLAECGKWHMFQPDTNSQCSVSS
EDIEKSFKTNPCGSISFTTSKFSYKIDFAEMKQMNLTTGKQRLIKRAPFSISAFSYICEN
EAIPMPPHWENVNTQVPYQLIPLHNQTHEYNEVANLFGKTMDRNRIKRIQRIQNLDLWEF
FCRKKAQLKKKRGVPQINEQMLFHGTSSEFVEAICIHNFDWRINGIHGAVFGKGTYFARD
AAYSSRFCKDDIKHGNTFQIHGVSLQQRHLFRTYKSMFLARVLIGDYINGDSKYMRPPSK
DGSYVNLYDSCVDDTWNPKIFVVFDANQIYPEYLIDFH
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| BDBM50594012 |
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| n/a |
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| Name | BDBM50594012 |
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| Synonyms: | CHEMBL5191676 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H14N4OS |
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| Mol. Mass. | 322.384 |
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| SMILES | CC#Cc1ccc2c(nc(CSc3ncccn3)[nH]c2=O)c1C |
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| Structure | 
|
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