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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Protein mono-ADP-ribosyltransferase PARP14 | ||
| Ligand | BDBM434101 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_2211539 (CHEMBL5124488) | ||
| IC50 | 300±n/a nM | ||
| Citation |  Nizi, MG; Maksimainen, MM; Lehtiö, L; Tabarrini, O Medicinal Chemistry Perspective on Targeting Mono-ADP-Ribosylating PARPs with Small Molecules. J Med Chem65:7532-7560 (2022) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Protein mono-ADP-ribosyltransferase PARP14 | |||
| Name: | Protein mono-ADP-ribosyltransferase PARP14 | ||
| Synonyms: | (ARTD8 or PARP14) | (ARTD8 or PARP14, Y1660L) | 2.4.2.- | 2.4.2.30 | ADP-ribosyltransferase diphtheria toxin-like 8 | ARTD8 | B aggressive lymphoma protein 2 | BAL2 | BAL2Â | Human diphtheria toxin-like ADP-ribosyltransferase (ARTD8 or PARP14, Y1660L) | KIAA1268 | KIAA1268 GN | KIAA1268 GN | PAR14_HUMAN | PARP-14 | PARP14 | Poly [ADP-ribose] polymerase 14 | Synonyms=BAL2 | ||
| Type: | n/a | ||
| Mol. Mass.: | 202812.41 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q460N5 | ||
| Residue: | 1801 | ||
| Sequence: |
| ||
| BDBM434101 | |||
| n/a | |||
| Name | BDBM434101 | ||
| Synonyms: | US10562891, Example 23 | US11008308, Example 23 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C16H20N2O2S | ||
| Mol. Mass. | 304.407 | ||
| SMILES | Cc1cccc2c1nc(CS[C@H]1CC[C@H](O)CC1)[nH]c2=O |r,wU:11.11,wD:14.15,(5.33,1.54,;5.33,,;6.67,-.77,;6.67,-2.31,;5.33,-3.08,;4,-2.31,;4,-.77,;2.67,,;1.33,-.77,;;-1.33,-.77,;-2.67,,;-4,-.77,;-5.33,,;-5.33,1.54,;-6.67,2.31,;-4,2.31,;-2.67,1.54,;1.33,-2.31,;2.67,-3.08,;2.67,-4.62,)| | ||
| Structure | 
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