| Reaction Details |
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 | Report a problem with these data |
| Target | Protein mono-ADP-ribosyltransferase PARP16 |
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| Ligand | BDBM50594267 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2211548 (CHEMBL5124497) |
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| IC50 | 362±n/a nM |
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| Citation |  Nizi, MG; Maksimainen, MM; Lehtiö, L; Tabarrini, O Medicinal Chemistry Perspective on Targeting Mono-ADP-Ribosylating PARPs with Small Molecules. J Med Chem65:7532-7560 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Protein mono-ADP-ribosyltransferase PARP16 |
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| Name: | Protein mono-ADP-ribosyltransferase PARP16 |
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| Synonyms: | 2.4.2.30 | ADP-ribosyltransferase diphtheria toxin-like 15 | ARTD15 | C15orf30 | Mono [ADP-ribose] polymerase PARP16 | PAR16_HUMAN | PARP-16 | PARP16 | Poly [ADP-ribose] polymerase 16 | Synonyms=ARTD15 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 36398.93 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_117586 |
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| Residue: | 322 |
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| Sequence: | MQPSGWAAAREAAGRDMLAADLRCSLFASALQSYKRDSVLRPFPASYARGDCKDFEALLA
DASKLPNLKELLQSSGDNHKRAWDLVSWILSSKVLTIHSAGKAEFEKIQKLTGAPHTPVP
APDFLFEIEYFDPANAKFYETKGERDLIYAFHGSRLENFHSIIHNGLHCHLNKTSLFGEG
TYLTSDLSLALIYSPHGHGWQHSLLGPILSCVAVCEVIDHPDVKCQTKKKDSKEIDRRRA
RIKHSEGGDIPPKYFVVTNNQLLRVKYLLVYSQKPPKRASSQLSWFSSHWFTVMISLYLL
LLLIVSVINSSAFQHFWNRAKR
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| BDBM50594267 |
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| n/a |
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| Name | BDBM50594267 |
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| Synonyms: | CHEMBL5189477 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H12Cl2N2O2 |
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| Mol. Mass. | 323.174 |
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| SMILES | O[C@@H]1[C@@H](CNC(=O)c2cc(Cl)c(Cl)cc12)c1ccccn1 |r| |
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| Structure | 
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