| Reaction Details |
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 | Report a problem with these data |
| Target | alpha-1,2-Mannosidase |
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| Ligand | BDBM50168996 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_305169 (CHEMBL832759) |
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| IC50 | 30000±n/a nM |
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| Citation |  Fiaux, H; Popowycz, F; Favre, S; Schütz, C; Vogel, P; Gerber-Lemaire, S; Juillerat-Jeanneret, L Functionalized pyrrolidines inhibit alpha-mannosidase activity and growth of human glioblastoma and melanoma cells. J Med Chem48:4237-46 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| alpha-1,2-Mannosidase |
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| Name: | alpha-1,2-Mannosidase |
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| Synonyms: | Alpha-mannosidase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 65344.50 |
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| Organism: | Glycine max |
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| Description: | ChEMBL_32380 |
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| Residue: | 578 |
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| Sequence: | MARGSRSVGSSSSKWRYCNPSYYLKRPKRLALLFIVFVCVSFVFWDRQTLVREHQVEISE
LQKEVTDLKNLVDDLNNKQGGTSGKTDLGRKATKSSKDVLDDPIDIERREKVKEAMLHAW
GSYEKYAWGQDELQPQSKNGVNSFGGLGATLIDSLDTLYIMGLNEQFQKAREWVANSLDF
NKDYEASVFETTIRVVGGLLSAYDLSGDKVFLDKAIEIADRLLPAWNTPTGIPYNIINLS
HGRAHNPSWTGGESILADSGTEQLEFIVLSQRTGDLKYQQKVENVIAQLNKTFPDDGLLP
IYINPHSGAAGYSPITFGAMGDSFYEYLLKVWIQGNKTSSIKHYRDMWEKSMKGLSSLIR
RSTPSSFTYICEKNGGSLTDKMDELACFAPGMIALGSFGYSAADDSQKFLSLAEELAWTC
YNFYQSTPTKLAGENYFFHSGQDMSVGTSWNILRPETVESLFYLWRLTGNKTYQEWGWNI
FQAFEKNSRIESGYVGLKDVNSGVKDNMMQSFFLAETLKYFYLLFSPSSVISLDEWVFNT
EAHPLRIVTRHEEGLVKNLNEKQKPFSRIGGRKEGRSG
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| BDBM50168996 |
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| n/a |
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| Name | BDBM50168996 |
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| Synonyms: | (2R,3R,4S)-2-{[(R)-2-(3-Fluoro-benzyloxy)-1-phenyl-ethylamino]-methyl}-pyrrolidine-3,4-diol | CHEMBL190418 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H25FN2O3 |
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| Mol. Mass. | 360.4225 |
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| SMILES | O[C@H]1CN[C@H](CNC(COCc2cccc(F)c2)c2ccccc2)[C@H]1O |
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| Structure | 
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