| Reaction Details |
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 | Report a problem with these data |
| Target | Plasmepsin I |
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| Ligand | BDBM50169103 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_302875 (CHEMBL828789) |
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| Ki | 0.4±n/a nM |
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| Citation |  Johansson, PO; Lindberg, J; Blackman, MJ; Kvarnström, I; Vrang, L; Hamelink, E; Hallberg, A; Rosenquist, A; Samuelsson, B Design and synthesis of potent inhibitors of plasmepsin I and II: X-ray crystal structure of inhibitor in complex with plasmepsin II. J Med Chem48:4400-9 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Plasmepsin I |
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| Name: | Plasmepsin I |
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| Synonyms: | PFAPG | PLM1_PLAFX | PMI | Plasmepsin 1 | Plasmepsin-1 precursor |
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| Type: | Enzyme |
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| Mol. Mass.: | 51463.30 |
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| Organism: | Plasmodium falciparum |
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| Description: | n/a |
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| Residue: | 452 |
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| Sequence: | MALSIKEDFSSAFAKNESAVNSSTFNNNMKTWKIQKRFQILYVFFFLLITGALFYYLIDN
VLFPKNKKINEIMNTSKHVIIGFSIENSHDRIMKTVKQHRLKNYIKESLKFFKTGLTQKP
HLGNAGDSVTLNDVANVMYYGEAQIGDNKQKFAFIFDTGSANLWVPSAQCNTIGCKTKNL
YDSNKSKTYEKDGTKVEMNYVSGTVSGFFSKDIVTIANLSFPYKFIEVTDTNGFEPAYTL
GQFDGIVGLGWKDLSIGSVDPVVVELKNQNKIEQAVFTFYLPFDDKHKGYLTIGGIEDRF
YEGQLTYEKLNHDLYWQVDLDLHFGNLTVEKATAIVDSGTSSITAPTEFLNKFFEGLDVV
KIPFLPLYITTCNNPKLPTLEFRSATNVYTLEPEYYLQQIFDFGISLCMVSIIPVDLNKN
TFILGDPFMRKYFTVFDYDNHTVGFALAKKKL
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| BDBM50169103 |
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| n/a |
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| Name | BDBM50169103 |
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| Synonyms: | CHEMBL191130 | Pyridine-2-carboxylic acid {(S)-1-[(1S,2S)-3-[(S)-1-((S)-1-aminomethyl-3-methyl-butylcarbamoyl)-ethylcarbamoyl]-1-(4-benzo[1,3]dioxol-5-yl-benzyloxymethyl)-2-hydroxy-propylcarbamoyl]-2-methyl-propyl}-amide |
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| Type | Small organic molecule |
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| Emp. Form. | C39H50N6O9 |
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| Mol. Mass. | 746.8491 |
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| SMILES | CC(C)C[C@H](NC(=O)[C@H](C)NC(=O)C[C@H](O)[C@H](COCc1ccc(cc1)-c1ccc2OCOc2c1)NC(=O)[C@@H](NC(=O)c1ccccn1)C(C)C)C(N)=O |
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| Structure | 
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