| Reaction Details |
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 | Report a problem with these data |
| Target | Cholesteryl ester transfer protein |
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| Ligand | BDBM50169273 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_306246 (CHEMBL831156) |
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| IC50 | 30±n/a nM |
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| Citation |  Brückner, D; Hafner, FT; Li, V; Schmeck, C; Telser, J; Vakalopoulos, A; Wirtz, G Dibenzodioxocinones--a new class of CETP inhibitors. Bioorg Med Chem Lett15:3611-4 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cholesteryl ester transfer protein |
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| Name: | Cholesteryl ester transfer protein |
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| Synonyms: | CETP | CETP_HUMAN | Cholesteryl ester transfer protein (CETP) | Lipid transfer protein I |
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| Type: | Enzyme |
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| Mol. Mass.: | 54751.53 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P11597 |
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| Residue: | 493 |
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| Sequence: | MLAATVLTLALLGNAHACSKGTSHEAGIVCRITKPALLVLNHETAKVIQTAFQRASYPDI
TGEKAMMLLGQVKYGLHNIQISHLSIASSQVELVEAKSIDVSIQNVSVVFKGTLKYGYTT
AWWLGIDQSIDFEIDSAIDLQINTQLTCDSGRVRTDAPDCYLSFHKLLLHLQGEREPGWI
KQLFTNFISFTLKLVLKGQICKEINVISNIMADFVQTRAASILSDGDIGVDISLTGDPVI
TASYLESHHKGHFIYKNVSEDLPLPTFSPTLLGDSRMLYFWFSERVFHSLAKVAFQDGRL
MLSLMGDEFKAVLETWGFNTNQEIFQEVVGGFPSQAQVTVHCLKMPKISCQNKGVVVNSS
VMVKFLFPRPDQQHSVAYTFEEDIVTTVQASYSKKKLFLSLLDFQITPKTVSNLTESSSE
SVQSFLQSMITAVGIPEVMSRLEVVFTALMNSKGVSLFDIINPEIITRDGFLLLQMDFGF
PEHLLVDFLQSLS
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| BDBM50169273 |
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| n/a |
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| Name | BDBM50169273 |
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| Synonyms: | 7-Methyl-bicyclo[2.2.1]heptane-7-carboxylic acid 9-chloro-2-((S)-1-hydroxy-3,3-dimethyl-butyl)-1-methoxy-7,8-dimethyl-11-oxo-11H-dibenzo[b,e][1,4]dioxepin-6-yl ester | CHEMBL362080 |
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| Type | Small organic molecule |
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| Emp. Form. | C31H37ClO7 |
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| Mol. Mass. | 557.074 |
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| SMILES | COc1c(ccc2Oc3c(OC(=O)C4(C)C5CCC4CC5)c(C)c(C)c(Cl)c3OC(=O)c12)[C@@H](O)CC(C)(C)C |TLB:11:13:19.20:16.17,THB:14:13:19.20:16.17| |
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| Structure | 
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