| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Broad substrate specificity ATP-binding cassette transporter ABCG2 |
|---|
| Ligand | BDBM50103596 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_2215559 (CHEMBL5128691) |
|---|
| IC50 | 460±n/a nM |
|---|
| Citation |  Zattoni, IF; Delabio, LC; Dutra, JP; Kita, DH; Scheiffer, G; Hembecker, M; Pereira, GDS; Moure, VR; Valdameri, G Targeting breast cancer resistance protein (BCRP/ABCG2): Functional inhibitors and expression modulators. Eur J Med Chem237:0 (2022) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Broad substrate specificity ATP-binding cassette transporter ABCG2 |
|---|
| Name: | Broad substrate specificity ATP-binding cassette transporter ABCG2 |
|---|
| Synonyms: | ABCG2 | ABCG2_HUMAN | ABCP | ATP-Binding Cassette Transporter ABCG2 | ATP-binding cassette sub-family G member 2 | ATP-binding cassette transporter (ABCG2) | ATP-binding cassette, sub-family G, member 2 | BCRP | BCRP1 | Breast cancer resistance protein | CDw338 | MXR | Mitoxantrone resistance-associated protein | Placenta-specific ATP-binding cassette transporter | Urate exporter |
|---|
| Type: | Multi-pass membrane protein; monomer or homodimer; disulfide-linked |
|---|
| Mol. Mass.: | 72329.48 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q9UNQ0 |
|---|
| Residue: | 655 |
|---|
| Sequence: | MSSSNVEVFIPVSQGNTNGFPATASNDLKAFTEGAVLSFHNICYRVKLKSGFLPCRKPVE
KEILSNINGIMKPGLNAILGPTGGGKSSLLDVLAARKDPSGLSGDVLINGAPRPANFKCN
SGYVVQDDVVMGTLTVRENLQFSAALRLATTMTNHEKNERINRVIQELGLDKVADSKVGT
QFIRGVSGGERKRTSIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRMSKQGRTIIF
SIHQPRYSIFKLFDSLTLLASGRLMFHGPAQEALGYFESAGYHCEAYNNPADFFLDIING
DSTAVALNREEDFKATEIIEPSKQDKPLIEKLAEIYVNSSFYKETKAELHQLSGGEKKKK
ITVFKEISYTTSFCHQLRWVSKRSFKNLLGNPQASIAQIIVTVVLGLVIGAIYFGLKNDS
TGIQNRAGVLFFLTTNQCFSSVSAVELFVVEKKLFIHEYISGYYRVSSYFLGKLLSDLLP
MRMLPSIIFTCIVYFMLGLKPKADAFFVMMFTLMMVAYSASSMALAIAAGQSVVSVATLL
MTICFVFMMIFSGLLVNLTTIASWLSWLQYFSIPRYGFTALQHNEFLGQNFCPGLNATGN
NPCNYATCTGEEYLVKQGIDLSPWGLWKNHVALACMIVIFLTIAYLKLLFLKKYS
|
|
|
|---|
| BDBM50103596 |
|---|
| n/a |
|---|
| Name | BDBM50103596 |
|---|
| Synonyms: | (E)-2-hydroxy-5-((4-(N-pyridin-2-ylsulfamoyl)-phenyl)diazenyl) benzoic acid (A8) | Azulfidine | Azulfidine EN | Azulfidine EN-Tabs | CHEBI:9334 | S.A.S. | S.A.S.-500 | SAS-500 | Salazopyrin | Salazosulfapyridine | Salicylazosulfapyridine | Sulfasalazine | Sulphasalazine | US11744839, Compound of formula 1 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C18H14N4O5S |
|---|
| Mol. Mass. | 398.393 |
|---|
| SMILES | OC(=O)c1cc(ccc1O)\N=N\c1ccc(cc1)S(=O)(=O)Nc1ccccn1 |
|---|
| Structure | 
|
|---|
Search and Browse
