| Reaction Details |
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 | Report a problem with these data |
| Target | cGMP-specific 3',5'-cyclic phosphodiesterase |
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| Ligand | BDBM50169632 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_304855 (CHEMBL828414) |
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| IC50 | 50±n/a nM |
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| Citation |  Haning, H; Niewöhner, U; Schenke, T; Lampe, T; Hillisch, A; Bischoff, E Comparison of different heterocyclic scaffolds as substrate analog PDE5 inhibitors. Bioorg Med Chem Lett15:3900-7 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| cGMP-specific 3',5'-cyclic phosphodiesterase |
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| Name: | cGMP-specific 3',5'-cyclic phosphodiesterase |
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| Synonyms: | 3',5'-cyclic phosphodiesterase | CGB-PDE | PDE5 | PDE5A | PDE5A_HUMAN | Phosphodiesterase 2 and 5 (PDE2 and PDE5) | Phosphodiesterase 5 (PDE5) | Phosphodiesterase 5A | Phosphodiesterase 5A (PDE5A) | cGMP-binding cGMP-specific phosphodiesterase | cGMP-specific 3',5'-cyclic phosphodiesterase |
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| Type: | Protein |
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| Mol. Mass.: | 99975.83 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O76074 |
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| Residue: | 875 |
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| Sequence: | MERAGPSFGQQRQQQQPQQQKQQQRDQDSVEAWLDDHWDFTFSYFVRKATREMVNAWFAE
RVHTIPVCKEGIRGHTESCSCPLQQSPRADNSAPGTPTRKISASEFDRPLRPIVVKDSEG
TVSFLSDSEKKEQMPLTPPRFDHDEGDQCSRLLELVKDISSHLDVTALCHKIFLHIHGLI
SADRYSLFLVCEDSSNDKFLISRLFDVAEGSTLEEVSNNCIRLEWNKGIVGHVAALGEPL
NIKDAYEDPRFNAEVDQITGYKTQSILCMPIKNHREEVVGVAQAINKKSGNGGTFTEKDE
KDFAAYLAFCGIVLHNAQLYETSLLENKRNQVLLDLASLIFEEQQSLEVILKKIAATIIS
FMQVQKCTIFIVDEDCSDSFSSVFHMECEELEKSSDTLTREHDANKINYMYAQYVKNTME
PLNIPDVSKDKRFPWTTENTGNVNQQCIRSLLCTPIKNGKKNKVIGVCQLVNKMEENTGK
VKPFNRNDEQFLEAFVIFCGLGIQNTQMYEAVERAMAKQMVTLEVLSYHASAAEEETREL
QSLAAAVVPSAQTLKITDFSFSDFELSDLETALCTIRMFTDLNLVQNFQMKHEVLCRWIL
SVKKNYRKNVAYHNWRHAFNTAQCMFAALKAGKIQNKLTDLEILALLIAALSHDLDHRGV
NNSYIQRSEHPLAQLYCHSIMEHHHFDQCLMILNSPGNQILSGLSIEEYKTTLKIIKQAI
LATDLALYIKRRGEFFELIRKNQFNLEDPHQKELFLAMLMTACDLSAITKPWPIQQRIAE
LVATEFFDQGDRERKELNIEPTDLMNREKKNKIPSMQVGFIDAICLQLYEALTHVSEDCF
PLLDGCRKNRQKWQALAEQQEKMLINGESGQAKRN
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| BDBM50169632 |
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| n/a |
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| Name | BDBM50169632 |
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| Synonyms: | 3-Cyclopentyl-6-{2-ethoxy-5-[4-(2-hydroxy-ethyl)-piperazine-1-sulfonyl]-phenyl}-7H-[1,2,4]triazolo[3,4-f][1,2,4]triazin-8-one | CHEMBL181916 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H31N7O5S |
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| Mol. Mass. | 517.601 |
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| SMILES | CCOc1ccc(cc1-c1nn2c(nnc2c(=O)[nH]1)C1CCCC1)S(=O)(=O)N1CCN(CCO)CC1 |
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| Structure | 
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