| Reaction Details |
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 | Report a problem with these data |
| Target | Nuclear factor of activated T-cells, cytoplasmic 1 |
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| Ligand | BDBM50595363 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2216480 (CHEMBL5129612) |
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| IC50 | 11600±n/a nM |
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| Citation |  Sánchez-Morales, A; Biçer, A; Panagiotopoulos, V; Crecente-Garcia, S; Benaiges, C; Bayod, S; Luís Hernández, J; Busqué, F; Matsoukas, MT; Pérez-Riba, M; Alibés, R Design and synthesis of a novel non peptide CN-NFATc signaling inhibitor for tumor suppression in triple negative breast cancer. Eur J Med Chem238:0 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Nuclear factor of activated T-cells, cytoplasmic 1 |
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| Name: | Nuclear factor of activated T-cells, cytoplasmic 1 |
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| Synonyms: | NF-ATc | NF-ATc1 | NFAC1_HUMAN | NFAT transcription complex cytosolic component | NFAT2 | NFATC | NFATC1 | Nuclear factor of activated T-cells cytoplasmic 1 | Nuclear factor of activated T-cells, cytoplasmic 1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 101251.15 |
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| Organism: | Homo sapiens |
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| Description: | ChEMBL_11335 |
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| Residue: | 943 |
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| Sequence: | MPSTSFPVPSKFPLGPAAAVFGRGETLGPAPRAGGTMKSAEEEHYGYASSNVSPALPLPT
AHSTLPAPCHNLQTSTPGIIPPADHPSGYGAALDGGPAGYFLSSGHTRPDGAPALESPRI
EITSCLGLYHNNNQFFHDVEVEDVLPSSKRSPSTATLSLPSLEAYRDPSCLSPASSLSSR
SCNSEASSYESNYSYPYASPQTSPWQSPCVSPKTTDPEEGFPRGLGACTLLGSPRHSPST
SPRASVTEESWLGARSSRPASPCNKRKYSLNGRQPPYSPHHSPTPSPHGSPRVSVTDDSW
LGNTTQYTSSAIVAAINALTTDSSLDLGDGVPVKSRKTTLEQPPSVALKVEPVGEDLGSP
PPPADFAPEDYSSFQHIRKGGFCDQYLAVPQHPYQWAKPKPLSPTSYMSPTLPALDWQLP
SHSGPYELRIEVQPKSHHRAHYETEGSRGAVKASAGGHPIVQLHGYLENEPLMLQLFIGT
ADDRLLRPHAFYQVHRITGKTVSTTSHEAILSNTKVLEIPLLPENSMRAVIDCAGILKLR
NSDIELRKGETDIGRKNTRVRLVFRVHVPQPSGRTLSLQVASNPIECSQRSAQELPLVEK
QSTDSYPVVGGKKMVLSGHNFLQDSKVIFVEKAPDGHHVWEMEAKTDRDLCKPNSLVVEI
PPFRNQRITSPVHVSFYVCNGKRKRSQYQRFTYLPANVPIIKTEPTDDYEPAPTCGPVSQ
GLSPLPRPYYSQQLAMPPDPSSCLVAGFPPCPQRSTLMPAAPGVSPKLHDLSPAAYTKGV
ASPGHCHLGLPQPAGEAPAVQDVPRPVATHPGSPGQPPPALLPQQVSAPPSSSCPPGLEH
SLCPSSPSPPLPPATQEPTCLQPCSPACPPATGRPQHLPSTVRRDESPTAGPRLLPEVHE
DGSPNLAPIPVTVKREPEELDQLYLDDVNEIIRNDLSSTSTHS
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| BDBM50595363 |
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| n/a |
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| Name | BDBM50595363 |
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| Synonyms: | CHEMBL5195853 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H17N3O3S |
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| Mol. Mass. | 343.4 |
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| SMILES | CS(=O)(=O)NCc1cccc(NC(=O)c2ccc3[nH]ccc3c2)c1 |
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| Structure | 
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