| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Nuclear factor of activated T-cells, cytoplasmic 1 |
|---|
| Ligand | BDBM50595364 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_2216480 (CHEMBL5129612) |
|---|
| IC50 | 18700±n/a nM |
|---|
| Citation |  Sánchez-Morales, A; Biçer, A; Panagiotopoulos, V; Crecente-Garcia, S; Benaiges, C; Bayod, S; Luís Hernández, J; Busqué, F; Matsoukas, MT; Pérez-Riba, M; Alibés, R Design and synthesis of a novel non peptide CN-NFATc signaling inhibitor for tumor suppression in triple negative breast cancer. Eur J Med Chem238:0 (2022) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Nuclear factor of activated T-cells, cytoplasmic 1 |
|---|
| Name: | Nuclear factor of activated T-cells, cytoplasmic 1 |
|---|
| Synonyms: | NF-ATc | NF-ATc1 | NFAC1_HUMAN | NFAT transcription complex cytosolic component | NFAT2 | NFATC | NFATC1 | Nuclear factor of activated T-cells cytoplasmic 1 | Nuclear factor of activated T-cells, cytoplasmic 1 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 101251.15 |
|---|
| Organism: | Homo sapiens |
|---|
| Description: | ChEMBL_11335 |
|---|
| Residue: | 943 |
|---|
| Sequence: | MPSTSFPVPSKFPLGPAAAVFGRGETLGPAPRAGGTMKSAEEEHYGYASSNVSPALPLPT
AHSTLPAPCHNLQTSTPGIIPPADHPSGYGAALDGGPAGYFLSSGHTRPDGAPALESPRI
EITSCLGLYHNNNQFFHDVEVEDVLPSSKRSPSTATLSLPSLEAYRDPSCLSPASSLSSR
SCNSEASSYESNYSYPYASPQTSPWQSPCVSPKTTDPEEGFPRGLGACTLLGSPRHSPST
SPRASVTEESWLGARSSRPASPCNKRKYSLNGRQPPYSPHHSPTPSPHGSPRVSVTDDSW
LGNTTQYTSSAIVAAINALTTDSSLDLGDGVPVKSRKTTLEQPPSVALKVEPVGEDLGSP
PPPADFAPEDYSSFQHIRKGGFCDQYLAVPQHPYQWAKPKPLSPTSYMSPTLPALDWQLP
SHSGPYELRIEVQPKSHHRAHYETEGSRGAVKASAGGHPIVQLHGYLENEPLMLQLFIGT
ADDRLLRPHAFYQVHRITGKTVSTTSHEAILSNTKVLEIPLLPENSMRAVIDCAGILKLR
NSDIELRKGETDIGRKNTRVRLVFRVHVPQPSGRTLSLQVASNPIECSQRSAQELPLVEK
QSTDSYPVVGGKKMVLSGHNFLQDSKVIFVEKAPDGHHVWEMEAKTDRDLCKPNSLVVEI
PPFRNQRITSPVHVSFYVCNGKRKRSQYQRFTYLPANVPIIKTEPTDDYEPAPTCGPVSQ
GLSPLPRPYYSQQLAMPPDPSSCLVAGFPPCPQRSTLMPAAPGVSPKLHDLSPAAYTKGV
ASPGHCHLGLPQPAGEAPAVQDVPRPVATHPGSPGQPPPALLPQQVSAPPSSSCPPGLEH
SLCPSSPSPPLPPATQEPTCLQPCSPACPPATGRPQHLPSTVRRDESPTAGPRLLPEVHE
DGSPNLAPIPVTVKREPEELDQLYLDDVNEIIRNDLSSTSTHS
|
|
|
|---|
| BDBM50595364 |
|---|
| n/a |
|---|
| Name | BDBM50595364 |
|---|
| Synonyms: | CHEMBL5181607 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C17H16N2O3S2 |
|---|
| Mol. Mass. | 360.451 |
|---|
| SMILES | CS(=O)(=O)NCc1cccc(NC(=O)c2csc3ccccc23)c1 |
|---|
| Structure | 
|
|---|
Search and Browse
