Reaction Details | |||
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Target | Muscarinic acetylcholine receptor M3 | ||
Ligand | BDBM50595408 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_2216667 (CHEMBL5129799) | ||
Ki | 1.6±n/a nM | ||
Citation | Carzaniga, L; Linney, ID; Rizzi, A; Delcanale, M; Schmidt, W; Knight, CK; Pastore, F; Miglietta, D; Carnini, C; Cesari, N; Riccardi, B; Mileo, V; Venturi, L; Moretti, E; Blackaby, WP; Patacchini, R; Accetta, A; Biagetti, M; Bassani, F; Tondelli, M; Murgo, A; Battipaglia, L; Villetti, G; Puccini, P; Catinella, S; Civelli, M; Rancati, F Discovery of Clinical Candidate CHF-6366: A Novel Super-soft Dual Pharmacology Muscarinic Antagonist and ? J Med Chem65:10233-10250 (2022) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Muscarinic acetylcholine receptor M3 | |||
Name: | Muscarinic acetylcholine receptor M3 | ||
Synonyms: | ACM3_HUMAN | CHRM3 | Cholinergic, muscarinic M3 | Muscarinic Receptors M3 | Muscarinic receptor M3 | RecName: Full=Muscarinic acetylcholine receptor M3 | ||
Type: | Enzyme | ||
Mol. Mass.: | 66151.03 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P20309 | ||
Residue: | 590 | ||
Sequence: |
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BDBM50595408 | |||
n/a | |||
Name | BDBM50595408 | ||
Synonyms: | CHEMBL5195203 | ||
Type | Small organic molecule | ||
Emp. Form. | C30H32N2O5 | ||
Mol. Mass. | 500.5855 | ||
SMILES | COC(=O)c1ccc(COc2cccc(c2)C(NC(=O)O[C@H]2CN3CCC2CC3)c2ccccc2)cc1 |r,wD:21.21,(-11.34,-1.54,;-10,-.77,;-8.67,-1.54,;-8.67,-3.08,;-7.34,-.77,;-6,-1.54,;-4.67,-.77,;-4.67,.77,;-3.33,1.54,;-2,.77,;-.67,1.54,;-.67,3.08,;.67,3.85,;2,3.08,;2,1.54,;.67,.77,;3.33,.77,;4.67,1.54,;6,.77,;6,-.77,;7.34,1.54,;8.67,.77,;8.67,-.77,;10,-1.54,;11.34,-.77,;11.34,.77,;10,1.54,;10.71,.31,;9.29,-.31,;3.33,-.77,;4.67,-1.54,;4.67,-3.08,;3.33,-3.85,;2,-3.08,;2,-1.54,;-6,1.54,;-7.34,.77,)| | ||
Structure |