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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Muscarinic acetylcholine receptor M3 | ||
| Ligand | BDBM50595413 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_2216667 (CHEMBL5129799) | ||
| Ki | 7.9±n/a nM | ||
| Citation |  Carzaniga, L; Linney, ID; Rizzi, A; Delcanale, M; Schmidt, W; Knight, CK; Pastore, F; Miglietta, D; Carnini, C; Cesari, N; Riccardi, B; Mileo, V; Venturi, L; Moretti, E; Blackaby, WP; Patacchini, R; Accetta, A; Biagetti, M; Bassani, F; Tondelli, M; Murgo, A; Battipaglia, L; Villetti, G; Puccini, P; Catinella, S; Civelli, M; Rancati, F Discovery of Clinical Candidate CHF-6366: A Novel Super-soft Dual Pharmacology Muscarinic Antagonist and ? J Med Chem65:10233-10250 (2022) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Muscarinic acetylcholine receptor M3 | |||
| Name: | Muscarinic acetylcholine receptor M3 | ||
| Synonyms: | ACM3_HUMAN | CHRM3 | Cholinergic, muscarinic M3 | Muscarinic Receptors M3 | Muscarinic receptor M3 | RecName: Full=Muscarinic acetylcholine receptor M3 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 66151.03 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P20309 | ||
| Residue: | 590 | ||
| Sequence: |
| ||
| BDBM50595413 | |||
| n/a | |||
| Name | BDBM50595413 | ||
| Synonyms: | CHEMBL5195224 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C27H28N2O5S | ||
| Mol. Mass. | 492.587 | ||
| SMILES | OC(=O)c1cc(COc2cccc(c2)[C@@H](NC(=O)O[C@H]2CN3CCC2CC3)c2ccccc2)cs1 |r,wU:14.15,wD:19.19,THB:18:19:22.23:25.26,(-9.91,-2.65,;-8.38,-2.49,;-7.48,-3.73,;-7.76,-1.08,;-6.25,-.76,;-6.09,.77,;-4.76,1.54,;-3.42,.77,;-2.09,1.54,;-2.09,3.08,;-.75,3.85,;.58,3.08,;.58,1.54,;-.75,.77,;1.91,.77,;3.25,1.54,;4.58,.77,;4.58,-.77,;5.91,1.54,;7.25,.77,;7.25,-.77,;8.58,-1.54,;7.87,-.31,;9.29,.31,;8.58,1.54,;9.91,.77,;9.91,-.77,;1.91,-.77,;3.25,-1.54,;3.25,-3.08,;1.91,-3.85,;.58,-3.08,;.58,-1.54,;-7.5,1.4,;-8.53,.25,)| | ||
| Structure | 
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