| Reaction Details |
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 | Report a problem with these data |
| Target | Histone deacetylase 4 |
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| Ligand | BDBM50595711 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2217565 (CHEMBL5130697) |
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| IC50 | 90±n/a nM |
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| Citation |  Macabuag, N; Esmieu, W; Breccia, P; Jarvis, R; Blackaby, W; Lazari, O; Urbonas, L; Eznarriaga, M; Williams, R; Strijbosch, A; Van de Bospoort, R; Matthews, K; Clissold, C; Ladduwahetty, T; Vater, H; Heaphy, P; Stafford, DG; Wang, HJ; Mangette, JE; McAllister, G; Beaumont, V; Vogt, TF; Wilkinson, HA; Doherty, EM; Dominguez, C Developing HDAC4-Selective Protein Degraders To Investigate the Role of HDAC4 in Huntington's Disease Pathology. J Med Chem65:12445-12459 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histone deacetylase 4 |
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| Name: | Histone deacetylase 4 |
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| Synonyms: | Cereblon/Histone deacetylase 4 | HD4 | HDAC4 | HDAC4_HUMAN | Histone acetylase 4(HDAC4) | Human HDAC4 | KIAA0288 |
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| Type: | Enzyme |
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| Mol. Mass.: | 119049.39 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P56524 |
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| Residue: | 1084 |
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| Sequence: | MSSQSHPDGLSGRDQPVELLNPARVNHMPSTVDVATALPLQVAPSAVPMDLRLDHQFSLP
VAEPALREQQLQQELLALKQKQQIQRQILIAEFQRQHEQLSRQHEAQLHEHIKQQQEMLA
MKHQQELLEHQRKLERHRQEQELEKQHREQKLQQLKNKEKGKESAVASTEVKMKLQEFVL
NKKKALAHRNLNHCISSDPRYWYGKTQHSSLDQSSPPQSGVSTSYNHPVLGMYDAKDDFP
LRKTASEPNLKLRSRLKQKVAERRSSPLLRRKDGPVVTALKKRPLDVTDSACSSAPGSGP
SSPNNSSGSVSAENGIAPAVPSIPAETSLAHRLVAREGSAAPLPLYTSPSLPNITLGLPA
TGPSAGTAGQQDAERLTLPALQQRLSLFPGTHLTPYLSTSPLERDGGAAHSPLLQHMVLL
EQPPAQAPLVTGLGALPLHAQSLVGADRVSPSIHKLRQHRPLGRTQSAPLPQNAQALQHL
VIQQQHQQFLEKHKQQFQQQQLQMNKIIPKPSEPARQPESHPEETEEELREHQALLDEPY
LDRLPGQKEAHAQAGVQVKQEPIESDEEEAEPPREVEPGQRQPSEQELLFRQQALLLEQQ
RIHQLRNYQASMEAAGIPVSFGGHRPLSRAQSSPASATFPVSVQEPPTKPRFTTGLVYDT
LMLKHQCTCGSSSSHPEHAGRIQSIWSRLQETGLRGKCECIRGRKATLEELQTVHSEAHT
LLYGTNPLNRQKLDSKKLLGSLASVFVRLPCGGVGVDSDTIWNEVHSAGAARLAVGCVVE
LVFKVATGELKNGFAVVRPPGHHAEESTPMGFCYFNSVAVAAKLLQQRLSVSKILIVDWD
VHHGNGTQQAFYSDPSVLYMSLHRYDDGNFFPGSGAPDEVGTGPGVGFNVNMAFTGGLDP
PMGDAEYLAAFRTVVMPIASEFAPDVVLVSSGFDAVEGHPTPLGGYNLSARCFGYLTKQL
MGLAGGRIVLALEGGHDLTAICDASEACVSALLGNELDPLPEKVLQQRPNANAVRSMEKV
MEIHSKYWRCLQRTTSTAGRSLIEAQTCENEEAETVTAMASLSVGVKPAEKRPDEEPMEE
EPPL
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| BDBM50595711 |
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| n/a |
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| Name | BDBM50595711 |
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| Synonyms: | CHEMBL5172806 |
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| Type | Small organic molecule |
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| Emp. Form. | C48H65F3N8O9S |
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| Mol. Mass. | 987.138 |
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| SMILES | CCCN(CCCCOCCOCCOCC(=O)N[C@H](C(=O)N1C[C@H](O)C[C@H]1C(=O)NCc1ccc(cc1)-c1scnc1C)C(C)(C)C)C[C@@H](C)NC(=O)c1ccc(cc1)-c1noc(n1)C(F)(F)F |r| |
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| Structure | 
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