| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase PLK3 |
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| Ligand | BDBM50596080 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2219404 (CHEMBL5132738) |
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| IC50 | 10000±n/a nM |
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| Citation |  Craig, SN; Baxter, M; Chapagai, D; Stafford, JM; Nurmemmedov, E; Altomare, D; Wyatt, MD; McInnes, C Structure-activity and mechanistic studies of non-peptidic inhibitors of the PLK1 polo box domain identified through REPLACE. Eur J Med Chem227:0 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine/threonine-protein kinase PLK3 |
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| Name: | Serine/threonine-protein kinase PLK3 |
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| Synonyms: | CNK | Cytokine-inducible serine/threonine-protein kinase | FGF-inducible kinase | FNK | PLK3 | PLK3_HUMAN | PRK | Polo-Like Kinase 3 | Proliferation-related kinase | Serine/threonine-protein kinase PLK3 |
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| Type: | Serine/threonine-protein kinase |
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| Mol. Mass.: | 71655.17 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Enzyme assays were using PLK3 purified from baculovirus-infected Trichoplusia ni cells expressing full-length PLK3. |
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| Residue: | 646 |
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| Sequence: | MEPAAGFLSPRPFQRAAAAPAPPAGPGPPPSALRGPELEMLAGLPTSDPGRLITDPRSGR
TYLKGRLLGKGGFARCYEATDTETGSAYAVKVIPQSRVAKPHQREKILNEIELHRDLQHR
HIVRFSHHFEDADNIYIFLELCSRKSLAHIWKARHTLLEPEVRYYLRQILSGLKYLHQRG
ILHRDLKLGNFFITENMELKVGDFGLAARLEPPEQRKKTICGTPNYVAPEVLLRQGHGPE
ADVWSLGCVMYTLLCGSPPFETADLKETYRCIKQVHYTLPASLSLPARQLLAAILRASPR
DRPSIDQILRHDFFTKGYTPDRLPISSCVTVPDLTPPNPARSLFAKVTKSLFGRKKKSKN
HAQERDEVSGLVSGLMRTSVGHQDARPEAPAASGPAPVSLVETAPEDSSPRGTLASSGDG
FEEGLTVATVVESALCALRNCIAFMPPAEQNPAPLAQPEPLVWVSKWVDYSNKFGFGYQL
SSRRVAVLFNDGTHMALSANRKTVHYNPTSTKHFSFSVGAVPRALQPQLGILRYFASYME
QHLMKGGDLPSVEEVEVPAPPLLLQWVKTDQALLMLFSDGTVQVNFYGDHTKLILSGWEP
LLVTFVARNRSACTYLASHLRQLGCSPDLRQRLRYALRLLRDRSPA
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| BDBM50596080 |
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| n/a |
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| Name | BDBM50596080 |
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| Synonyms: | CHEMBL5182503 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H26N2O5 |
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| Mol. Mass. | 398.4522 |
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| SMILES | CCCCCCCCc1ccc(cc1)C(=O)Nc1cccc(c1C(O)=O)[N+]([O-])=O |
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| Structure | 
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