Reaction Details |
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Target | Endothelin-converting enzyme 1 |
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Ligand | BDBM50171616 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_321543 (CHEMBL881481) |
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IC50 | 660.0±n/a nM |
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Citation | Brands, M; Ergüden, JK; Hashimoto, K; Heimbach, D; Schröder, C; Siegel, S; Stasch, JP; Weigand, S Novel, selective indole-based ECE inhibitors: lead optimization via solid-phase and classical synthesis. Bioorg Med Chem Lett15:4201-5 (2005) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Endothelin-converting enzyme 1 |
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Name: | Endothelin-converting enzyme 1 |
Synonyms: | ECE-1 | ECE1 | ECE1_HUMAN | Endothelin-Converting Enzyme 1 | Endothelin-converting enzyme 1 (ECE1) |
Type: | Enzyme |
Mol. Mass.: | 87155.11 |
Organism: | Homo sapiens (Human) |
Description: | P42892 |
Residue: | 770 |
Sequence: | MRGVWPPPVSALLSALGMSTYKRATLDEEDLVDSLSEGDAYPNGLQVNFHSPRSGQRCWA
ARTQVEKRLVVLVVLLAAGLVACLAALGIQYQTRSPSVCLSEACVSVTSSILSSMDPTVD
PCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLENSTASVSEAERKAQV
YYRACMNETRIEELRAKPLMELIERLGGWNITGPWAKDNFQDTLQVVTAHYRTSPFFSVY
VSADSKNSNSNVIQVDQSGLGLPSRDYYLNKTENEKVLTGYLNYMVQLGKLLGGGDEEAI
RPQMQQILDFETALANITIPQEKRRDEELIYHKVTAAELQTLAPAINWLPFLNTIFYPVE
INESEPIVVYDKEYLEQISTLINTTDRCLLNNYMIWNLVRKTSSFLDQRFQDADEKFMEV
MYGTKKTCLPRWKFCVSDTENNLGFALGPMFVKATFAEDSKSIATEIILEIKKAFEESLS
TLKWMDEETRKSAKEKADAIYNMIGYPNFIMDPKELDKVFNDYTAVPDLYFENAMRFFNF
SWRVTADQLRKAPNRDQWSMTPPMVNAYYSPTKNEIVFPAGILQAPFYTRSSPKALNFGG
IGVVVGHELTHAFDDQGREYDKDGNLRPWWKNSSVEAFKRQTECMVEQYSNYSVNGEPVN
GRHTLGENIADNGGLKAAYRAYQNWVKKNGAEHSLPTLGLTNNQLFFLGFAQVWCSVRTP
ESSHEGLITDPHSPSRFRVIGSLSNSKEFSEHFRCPPGSPMNPPHKCEVW
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BDBM50171616 |
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n/a |
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Name | BDBM50171616 |
Synonyms: | 5-(3,3-Dimethyl-thiobutyrylamino)-1-(2-fluoro-benzyl)-1H-indole-2-carboxylic acid phenylamide | CHEMBL194739 |
Type | Small organic molecule |
Emp. Form. | C28H28FN3OS |
Mol. Mass. | 473.605 |
SMILES | CC(C)(C)CC(=S)Nc1ccc2n(Cc3ccccc3F)c(cc2c1)C(=O)Nc1ccccc1 |
Structure |
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