| Reaction Details |
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 | Report a problem with these data |
| Target | Synaptic vesicular amine transporter |
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| Ligand | BDBM50080818 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_320964 (CHEMBL885371) |
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| Ki | 6260±n/a nM |
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| Citation |  Zheng, G; Dwoskin, LP; Deaciuc, AG; Crooks, PA Synthesis and evaluation of a series of tropane analogues as novel vesicular monoamine transporter-2 ligands. Bioorg Med Chem Lett15:4463-6 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Synaptic vesicular amine transporter |
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| Name: | Synaptic vesicular amine transporter |
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| Synonyms: | Monoamine transporter | Slc18a2 | Solute carrier family 18 member 2 | Svat | Synaptic vesicular amine transporter | VAT2 | VMAT2_RAT | Vesicular amine transporter 2 | Vesicular monoamine transporter 2 (VMAT2) | Vmat2 |
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| Type: | Protein |
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| Mol. Mass.: | 55689.58 |
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| Organism: | Rattus norvegicus (Rat) |
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| Description: | Q01827 |
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| Residue: | 515 |
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| Sequence: | MALSDLVLLRWLRDSRHSRKLILFIVFLALLLDNMLLTVVVPIIPSYLYSIKHEKNSTEI
QTTRPELVVSTSESIFSYYNNSTVLITGNATGTLPGGQSHKATSTQHTVANTTVPSDCPS
EDRDLLNENVQVGLLFASKATVQLLTNPFIGLLTNRIGYPIPMFAGFCIMFISTVMFAFS
SSYAFLLIARSLQGIGSSCSSVAGMGMLASVYTDDEERGKPMGIALGGLAMGVLVGPPFG
SVLYEFVGKTAPFLVLAALVLLDGAIQLFVLQPSRVQPESQKGTPLTTLLKDPYILIAAG
SICFANMGIAMLEPALPIWMMETMCSRKWQLGVAFLPASISYLIGTNIFGILAHKMGRWL
CALLGMVIVGISILCIPFAKNIYGLIAPNFGVGFAIGMVDSSMMPIMGYLVDLRHVSVYG
SVYAIADVAFCMGYAIGPSAGGAIAKAIGFPWLMTIIGIIDIAFAPLCFFLRSPPAKEEK
MAILMDHNCPIKRKMYTQNNVQSYPIGDDEESESD
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| BDBM50080818 |
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| n/a |
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| Name | BDBM50080818 |
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| Synonyms: | (-)-lobeline | 2-(6-(2-Hydroxy-2-phenylethyl)-1-methyl-2-piperidinyl)-1-phenylethanone | 2-(6-(beta-Hydroxyphenethyl)-1-methyl-2-piperidyl)acetophenone | 2-{(2R,6S)-6-[(2S)-2-hydroxy-2-phenylethyl]-1-methylpiperidin-2-yl}-1-phenylethanone | 8,10-Diphenyllobelionol | CHEMBL122270 | Lobelin | Lobnico | alpha-Lobeline |
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| Type | Small organic molecule |
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| Emp. Form. | C22H27NO2 |
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| Mol. Mass. | 337.4553 |
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| SMILES | CN1[C@H](C[C@H](O)c2ccccc2)CCC[C@@H]1CC(=O)c1ccccc1 |r| |
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| Structure | 
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