| Reaction Details |
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 | Report a problem with these data |
| Target | Synaptic vesicular amine transporter |
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| Ligand | BDBM50172090 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_320963 (CHEMBL885370) |
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| Ki | 1380±n/a nM |
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| Citation |  Zheng, G; Dwoskin, LP; Deaciuc, AG; Crooks, PA Synthesis and evaluation of a series of tropane analogues as novel vesicular monoamine transporter-2 ligands. Bioorg Med Chem Lett15:4463-6 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Synaptic vesicular amine transporter |
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| Name: | Synaptic vesicular amine transporter |
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| Synonyms: | Monoamine transporter | Slc18a2 | Solute carrier family 18 member 2 | Svat | Synaptic vesicular amine transporter | VAT2 | VMAT2_RAT | Vesicular amine transporter 2 | Vesicular monoamine transporter 2 (VMAT2) | Vmat2 |
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| Type: | Protein |
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| Mol. Mass.: | 55689.58 |
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| Organism: | Rattus norvegicus (Rat) |
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| Description: | Q01827 |
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| Residue: | 515 |
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| Sequence: | MALSDLVLLRWLRDSRHSRKLILFIVFLALLLDNMLLTVVVPIIPSYLYSIKHEKNSTEI
QTTRPELVVSTSESIFSYYNNSTVLITGNATGTLPGGQSHKATSTQHTVANTTVPSDCPS
EDRDLLNENVQVGLLFASKATVQLLTNPFIGLLTNRIGYPIPMFAGFCIMFISTVMFAFS
SSYAFLLIARSLQGIGSSCSSVAGMGMLASVYTDDEERGKPMGIALGGLAMGVLVGPPFG
SVLYEFVGKTAPFLVLAALVLLDGAIQLFVLQPSRVQPESQKGTPLTTLLKDPYILIAAG
SICFANMGIAMLEPALPIWMMETMCSRKWQLGVAFLPASISYLIGTNIFGILAHKMGRWL
CALLGMVIVGISILCIPFAKNIYGLIAPNFGVGFAIGMVDSSMMPIMGYLVDLRHVSVYG
SVYAIADVAFCMGYAIGPSAGGAIAKAIGFPWLMTIIGIIDIAFAPLCFFLRSPPAKEEK
MAILMDHNCPIKRKMYTQNNVQSYPIGDDEESESD
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| BDBM50172090 |
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| n/a |
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| Name | BDBM50172090 |
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| Synonyms: | (4S)-2,4-bis(4-fluorobenzyl)-8-methyl-8-azabicyclo[3.2.1]oct-2-ene | CHEMBL363778 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H23F2N |
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| Mol. Mass. | 339.4215 |
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| SMILES | CN1C2CCC1C(Cc1ccc(F)cc1)=C[C@@H]2Cc1ccc(F)cc1 |c:16,TLB:7:6:1:4.3,THB:17:16:1:4.3| |
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| Structure | 
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