| Reaction Details |
|---|
 | Report a problem with these data |
| Target | P2X purinoceptor 2 |
|---|
| Ligand | BDBM50596627 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_2221594 (CHEMBL5134928) |
|---|
| IC50 | 2306±n/a nM |
|---|
| Citation |  Mahmood, A; Ali Shah, SJ; Iqbal, J Design and synthesis of adamantane-1-carbonyl thiourea derivatives as potent and selective inhibitors of h-P2X4 and h-P2X7 receptors: An Emerging therapeutic tool for treatment of inflammation and neurological disorders. Eur J Med Chem231:0 (2022) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| P2X purinoceptor 2 |
|---|
| Name: | P2X purinoceptor 2 |
|---|
| Synonyms: | ATP receptor | P2RX2 | P2RX2_HUMAN | P2X2 | Purinergic receptor | PurinergicP2X2/3 |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 51765.18 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | PurinergicP2X2/3 0 HUMAN::Q9UBL9 |
|---|
| Residue: | 471 |
|---|
| Sequence: | MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYV
FIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQ
TQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVED
GASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFK
LGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYN
FRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCD
WILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSG
QEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL
|
|
|
|---|
| BDBM50596627 |
|---|
| n/a |
|---|
| Name | BDBM50596627 |
|---|
| Synonyms: | CHEMBL5183204 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C19H24N2O2S |
|---|
| Mol. Mass. | 344.471 |
|---|
| SMILES | COc1cccc(NC(=S)NC(=O)C23CC4CC(CC(C4)C2)C3)c1 |TLB:20:19:22:16.15.14,20:15:22:19.21.18,THB:18:19:22.17.16:14,18:17:19.21.20:14| |
|---|
| Structure | 
|
|---|
Search and Browse
