Reaction Details |
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Target | P2X purinoceptor 4 |
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Ligand | BDBM50596637 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_2221595 (CHEMBL5134929) |
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IC50 | 1274±n/a nM |
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Citation | Mahmood, A; Ali Shah, SJ; Iqbal, J Design and synthesis of adamantane-1-carbonyl thiourea derivatives as potent and selective inhibitors of h-P2X4 and h-P2X7 receptors: An Emerging therapeutic tool for treatment of inflammation and neurological disorders. Eur J Med Chem231:0 (2022) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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P2X purinoceptor 4 |
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Name: | P2X purinoceptor 4 |
Synonyms: | ATP receptor | P2RX4 | P2RX4_HUMAN | P2X4 | Purinergic receptor | Purinergic, P2X4 |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 43374.70 |
Organism: | Homo sapiens (Human) |
Description: | Purinergic, P2X4 0 HUMAN::Q99571 |
Residue: | 388 |
Sequence: | MAGCCAALAAFLFEYDTPRIVLIRSRKVGLMNRAVQLLILAYVIGWVFVWEKGYQETDSV
VSSVTTKVKGVAVTNTSKLGFRIWDVADYVIPAQEENSLFVMTNVILTMNQTQGLCPEIP
DATTVCKSDASCTAGSAGTHSNGVSTGRCVAFNGSVKTCEVAAWCPVEDDTHVPQPAFLK
AAENFTLLVKNNIWYPKFNFSKRNILPNITTTYLKSCIYDAKTDPFCPIFRLGKIVENAG
HSFQDMAVEGGIMGIQVNWDCNLDRAASLCLPRYSFRRLDTRDVEHNVSPGYNFRFAKYY
RDLAGNEQRTLIKAYGIRFDIIVFGKAGKFDIIPTMINIGSGLALLGMATVLCDIIVLYC
MKKRLYYREKKYKYVEDYEQGLASELDQ
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BDBM50596637 |
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n/a |
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Name | BDBM50596637 |
Synonyms: | CHEMBL5188202 |
Type | Small organic molecule |
Emp. Form. | C17H20ClN3OS |
Mol. Mass. | 349.878 |
SMILES | Clc1ncccc1NC(=S)NC(=O)C12CC3CC(CC(C3)C1)C2 |TLB:20:19:22:16.15.14,20:15:22:19.21.18,THB:18:19:22.17.16:14,18:17:19.21.20:14| |
Structure |
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