| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein kinase Tec |
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| Ligand | BDBM50175583 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2222498 (CHEMBL5135832) |
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| IC50 | 126±n/a nM |
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| Citation |  Singh, J The Ascension of Targeted Covalent Inhibitors. J Med Chem65:5886-5901 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Tyrosine-protein kinase Tec |
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| Name: | Tyrosine-protein kinase Tec |
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| Synonyms: | PSCTK4 | TEC | TEC_HUMAN | Tyrosine-protein kinase TEC (TEC) |
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| Type: | Protein |
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| Mol. Mass.: | 73597.00 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 631 |
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| Sequence: | MNFNTILEEILIKRSQQKKKTSPLNYKERLFVLTKSMLTYYEGRAEKKYRKGFIDVSKIK
CVEIVKNDDGVIPCQNKYPFQVVHDANTLYIFAPSPQSRDLWVKKLKEEIKNNNNIMIKY
HPKFWTDGSYQCCRQTEKLAPGCEKYNLFESSIRKALPPAPETKKRRPPPPIPLEEEDNS
EEIVVAMYDFQAAEGHDLRLERGQEYLILEKNDVHWWRARDKYGNEGYIPSNYVTGKKSN
NLDQYEWYCRNMNRSKAEQLLRSEDKEGGFMVRDSSQPGLYTVSLYTKFGGEGSSGFRHY
HIKETTTSPKKYYLAEKHAFGSIPEIIEYHKHNAAGLVTRLRYPVSVKGKNAPTTAGFSY
EKWEINPSELTFMRELGSGLFGVVRLGKWRAQYKVAIKAIREGAMCEEDFIEEAKVMMKL
THPKLVQLYGVCTQQKPIYIVTEFMERGCLLNFLRQRQGHFSRDVLLSMCQDVCEGMEYL
ERNSFIHRDLAARNCLVSEAGVVKVSDFGMARYVLDDQYTSSSGAKFPVKWCPPEVFNYS
RFSSKSDVWSFGVLMWEVFTEGRMPFEKYTNYEVVTMVTRGHRLYQPKLASNYVYEVMLR
CWQEKPEGRPSFEDLLRTIDELVECEETFGR
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| BDBM50175583 |
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| n/a |
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| Name | BDBM50175583 |
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| Synonyms: | ACP-196 | Acalabrutinib | US10239883, Example 6 | US10793576, Example ACP-196 | US10919899, ACP-196 | US10934296, Example 6 | US11420975, Acalabrutinlb | US9758524, Example 6 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H23N7O2 |
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| Mol. Mass. | 465.5065 |
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| SMILES | [H][C@]1(CCCN1C(=O)C#CC)c1nc(-c2ccc(cc2)C(=O)Nc2ccccn2)c2c(N)nccn12 |r| |
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| Structure | 
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