| Reaction Details |
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 | Report a problem with these data |
| Target | B-cell lymphoma 6 protein |
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| Ligand | BDBM50597101 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2222867 (CHEMBL5136201) |
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| IC50 | 5500±n/a nM |
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| Citation |  Davis, OA; Cheung, KJ; Brennan, A; Lloyd, MG; Rodrigues, MJ; Pierrat, OA; Collie, GW; Le Bihan, YV; Huckvale, R; Harnden, AC; Varela, A; Bright, MD; Eve, P; Hayes, A; Henley, AT; Carter, MD; McAndrew, PC; Talbot, R; Burke, R; van Montfort, RLM; Raynaud, FI; Rossanese, OW; Meniconi, M; Bellenie, BR; Hoelder, S Optimizing Shape Complementarity Enables the Discovery of Potent Tricyclic BCL6 Inhibitors. J Med Chem65:8169-8190 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| B-cell lymphoma 6 protein |
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| Name: | B-cell lymphoma 6 protein |
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| Synonyms: | B-cell lymphoma 5 protein | B-cell lymphoma 6 protein | BCL-5 | BCL-6 | BCL5 | BCL6 | BCL6_HUMAN | BCoR-BCL6 | LAZ3 | Protein LAZ-3 | ZBTB27 | ZNF51 | Zinc finger and BTB domain-containing protein 27 | Zinc finger protein 51 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 78866.89 |
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| Organism: | Homo sapiens |
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| Description: | ChEMBL_117695 |
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| Residue: | 706 |
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| Sequence: | MASPADSCIQFTRHASDVLLNLNRLRSRDILTDVVIVVSREQFRAHKTVLMACSGLFYSI
FTDQLKCNLSVINLDPEINPEGFCILLDFMYTSRLNLREGNIMAVMATAMYLQMEHVVDT
CRKFIKASEAEMVSAIKPPREEFLNSRMLMPQDIMAYRGREVVENNLPLRSAPGCESRAF
APSLYSGLSTPPASYSMYSHLPVSSLLFSDEEFRDVRMPVANPFPKERALPCDSARPVPG
EYSRPTLEVSPNVCHSNIYSPKETIPEEARSDMHYSVAEGLKPAAPSARNAPYFPCDKAS
KEEERPSSEDEIALHFEPPNAPLNRKGLVSPQSPQKSDCQPNSPTESCSSKNACILQASG
SPPAKSPTDPKACNWKKYKFIVLNSLNQNAKPEGPEQAELGRLSPRAYTAPPACQPPMEP
ENLDLQSPTKLSASGEDSTIPQASRLNNIVNRSMTGSPRSSSESHSPLYMHPPKCTSCGS
QSPQHAEMCLHTAGPTFPEEMGETQSEYSDSSCENGAFFCNECDCRFSEEASLKRHTLQT
HSDKPYKCDRCQASFRYKGNLASHKTVHTGEKPYRCNICGAQFNRPANLKTHTRIHSGEK
PYKCETCGARFVQVAHLRAHVLIHTGEKPYPCEICGTRFRHLQTLKSHLRIHTGEKPYHC
EKCNLHFRHKSQLRLHLRQKHGAITNTKVQYRVSATDLPPELPKAC
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| BDBM50597101 |
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| n/a |
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| Name | BDBM50597101 |
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| Synonyms: | CHEMBL5207801 | US20230287003, Example 1b |
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| Type | Small organic molecule |
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| Emp. Form. | C20H18ClN5O2 |
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| Mol. Mass. | 395.842 |
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| SMILES | C[C@@H]1CCOc2c(N1)c1cc(Nc3ccnc(Cl)c3C#N)ccc1n(C)c2=O |r| |
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| Structure | 
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