| Reaction Details |
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 | Report a problem with these data |
| Target | Neuronal acetylcholine receptor; alpha9/alpha10 |
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| Ligand | BDBM50597505 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2223585 (CHEMBL5136919) |
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| IC50 | 18±n/a nM |
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| Citation |  Bavo, F; Pallavicini, M; Pucci, S; Appiani, R; Giraudo, A; Eaton, B; Lucero, L; Gotti, C; Moretti, M; Whiteaker, P; Bolchi, C From 2-Triethylammonium Ethyl Ether of 4-Stilbenol (MG624) to Selective Small-Molecule Antagonists of Human ?9?10 Nicotinic Receptor by Modifications at the Ammonium Ethyl Residue. J Med Chem65:10079-10097 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Neuronal acetylcholine receptor; alpha9/alpha10 |
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| Name: | Neuronal acetylcholine receptor; alpha9/alpha10 |
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| Synonyms: | Neuronal acetylcholine receptor protein alpha-10/alpha-9 subunit | Neuronal acetylcholine receptor subunit alpha-10/alpha-9 |
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| Type: | n/a |
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| Mol. Mass.: | n/a |
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| Description: | ASSAY_ID of ChEMBL is 2150170 |
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| Components: | This complex has 2 components. |
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| Component 1 |
| Name: | Neuronal acetylcholine receptor subunit alpha-9 |
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| Synonyms: | ACHA9_HUMAN | CHRNA9 | NACHR alpha-9 | NACHRA9 | Neuronal acetylcholine receptor protein alpha-9 subunit | Neuronal acetylcholine receptor subunit alpha-9 | Nicotinic acetylcholine receptor subunit alpha-9 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 54806.10 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_306102 |
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| Residue: | 479 |
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| Sequence: | MNWSHSCISFCWIYFAASRLRAAETADGKYAQKLFNDLFEDYSNALRPVEDTDKVLNVTL
QITLSQIKDMDERNQILTAYLWIRQIWHDAYLTWDRDQYDGLDSIRIPSDLVWRPDIVLY
NKADDESSEPVNTNVVLRYDGLITWDAPAITKSSCVVDVTYFPFDNQQCNLTFGSWTYNG
NQVDIFNALDSGDLSDFIEDVEWEVHGMPAVKNVISYGCCSEPYPDVTFTLLLKRRSSFY
IVNLLIPCVLISFLAPLSFYLPAASGEKVSLGVTILLAMTVFQLMVAEIMPASENVPLIG
KYYIATMALITASTALTIMVMNIHFCGAEARPVPHWARVVILKYMSRVLFVYDVGESCLS
PHHSRERDHLTKVYSKLPESNLKAARNKDLSRKKDMNKRLKNDLGCQGKNPQEAESYCAQ
YKVLTRNIEYIAKCLKDHKATNSKGSEWKKVAKVIDRFFMWIFFIMVFVMTILIIARAD
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| Component 2 |
| Name: | Neuronal acetylcholine receptor subunit alpha-10 |
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| Synonyms: | ACH10_HUMAN | CHRNA10 | NACHRA10 | Neuronal acetylcholine receptor protein alpha-10 subunit |
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| Type: | PROTEIN |
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| Mol. Mass.: | 49714.45 |
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| Organism: | Homo sapiens (Human) |
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| Description: | EBI_12740 |
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| Residue: | 450 |
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| Sequence: | MGLRSHHLSLGLLLLFLLPAECLGAEGRLALKLFRDLFANYTSALRPVADTDQTLNVTLE
VTLSQIIDMDERNQVLTLYLWIRQEWTDAYLRWDPNAYGGLDAIRIPSSLVWRPDIVLYN
KADAQPPGSASTNVVLRHDGAVRWDAPAITRSSCRVDVAAFPFDAQHCGLTFGSWTHGGH
QLDVRPRGAAASLADFVENVEWRVLGMPARRRVLTYGCCSEPYPDVTFTLLLRRRAAAYV
CNLLLPCVLISLLAPLAFHLPADSGEKVSLGVTVLLALTVFQLLLAESMPPAESVPLIGK
YYMATMTMVTFSTALTILIMNLHYCGPSVRPVPAWARALLLGHLARGLCVRERGEPCGQS
RPPELSPSPQSPEGGAGPPAGPCHEPRCLCRQEALLHHVATIANTFRSHRAAQRCHEDWK
RLARVMDRFFLAIFFSMALVMSLLVLVQAL
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| BDBM50597505 |
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| n/a |
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| Name | BDBM50597505 |
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| Synonyms: | CHEMBL5174508 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H24INO |
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| Mol. Mass. | 421.3151 |
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| SMILES | [I-].C[N+]1(CCOc2ccc(\C=C\c3ccccc3)cc2)CCC1 |
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| Structure | 
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