| Reaction Details |
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 | Report a problem with these data |
| Target | C-X-C chemokine receptor type 3 |
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| Ligand | BDBM50175187 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_329075 (CHEMBL862999) |
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| IC50 | 70±n/a nM |
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| Citation |  Cole, AG; Stroke, IL; Brescia, MR; Simhadri, S; Zhang, JJ; Hussain, Z; Snider, M; Haskell, C; Ribeiro, S; Appell, KC; Henderson, I; Webb, ML Identification and initial evaluation of 4-N-aryl-[1,4]diazepane ureas as potent CXCR3 antagonists. Bioorg Med Chem Lett16:200-3 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| C-X-C chemokine receptor type 3 |
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| Name: | C-X-C chemokine receptor type 3 |
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| Synonyms: | AAO92295.1 | C-X-C chemokine receptor type 3 | C-X-C chemokine receptor type 3 (CXCR3) | C-X-C chemokine receptor type 3 (CXCR3A) | CXCR3 | CXCR3A | CXCR3_HUMAN | GPR9 | chemokine (C-X-C motif) receptor 3 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 40665.65 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 368 |
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| Sequence: | MVLEVSDHQVLNDAEVAALLENFSSSYDYGENESDSCCTSPPCPQDFSLNFDRAFLPALY
SLLFLLGLLGNGAVAAVLLSRRTALSSTDTFLLHLAVADTLLVLTLPLWAVDAAVQWVFG
SGLCKVAGALFNINFYAGALLLACISFDRYLNIVHATQLYRRGPPARVTLTCLAVWGLCL
LFALPDFIFLSAHHDERLNATHCQYNFPQVGRTALRVLQLVAGFLLPLLVMAYCYAHILA
VLLVSRGQRRLRAMRLVVVVVVAFALCWTPYHLVVLVDILMDLGALARNCGRESRVDVAK
SVTSGLGYMHCCLNPLLYAFVGVKFRERMWMLLLRLGCPNQRGLQRQPSSSRRDSSWSET
SEASYSGL
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| BDBM50175187 |
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| n/a |
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| Name | BDBM50175187 |
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| Synonyms: | 4-(4-((2,4-dichlorophenethyl)carbamoyl)-2-benzamidophenyl)-N-ethyl-1,4-diazepane-1-carboxamide | CHEMBL197818 |
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| Type | Small organic molecule |
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| Emp. Form. | C30H33Cl2N5O3 |
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| Mol. Mass. | 582.521 |
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| SMILES | CCNC(=O)N1CCCN(CC1)c1ccc(cc1NC(=O)c1ccccc1)C(=O)NCCc1ccc(Cl)cc1Cl |
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| Structure | 
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