Reaction Details |
![](/images/Email.png) | Report a problem with these data |
Target | Cytochrome P450 2D6 |
---|
Ligand | BDBM50175833 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_327755 (CHEMBL861796) |
---|
IC50 | 40±n/a nM |
---|
Citation | Vaccaro, WD; Sher, R; Berlin, M; Shih, NY; Aslanian, R; Schwerdt, JH; McCormick, KD; Piwinski, JJ; West, RE; Anthes, JC; Williams, SM; Wu, RL; She, HS; Rivelli, MA; Mutter, JC; Corboz, MR; Hey, JA; Favreau, L Novel histamine H3 receptor antagonists based on the 4-[(1H-imidazol-4-yl)methyl]piperidine scaffold. Bioorg Med Chem Lett16:395-9 (2005) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Cytochrome P450 2D6 |
---|
Name: | Cytochrome P450 2D6 |
Synonyms: | CP2D6_HUMAN | CYP2D6 | CYP2DL1 | CYPIID6 | Cytochrome P450 2D6 (CYP2D6) | Debrisoquine 4-hydroxylase | P450-DB1 |
Type: | Protein |
Mol. Mass.: | 55774.82 |
Organism: | Homo sapiens (Human) |
Description: | P10635 |
Residue: | 497 |
Sequence: | MGLEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQ
LRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVF
LARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDK
AVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHIPALAGKV
LRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVA
DLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVI
HEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHF
LDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGV
FAFLVSPSPYELCAVPR
|
|
|
BDBM50175833 |
---|
n/a |
---|
Name | BDBM50175833 |
Synonyms: | 3-(4-((1H-imidazol-4-yl)methyl)piperidin-1-yl)-N-(4-chlorophenyl)propanamide | CHEMBL371730 |
Type | Small organic molecule |
Emp. Form. | C18H23ClN4O |
Mol. Mass. | 346.854 |
SMILES | Clc1ccc(NC(=O)CCN2CCC(Cc3cnc[nH]3)CC2)cc1 |
Structure |
|