| Reaction Details |
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 | Report a problem with these data |
| Target | Tryptophan 5-hydroxylase 1 |
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| Ligand | BDBM357735 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2228293 (CHEMBL5141806) |
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| IC50 | 300±n/a nM |
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| Citation |  Specker, E; Matthes, S; Wesolowski, R; Schütz, A; Grohmann, M; Alenina, N; Pleimes, D; Mallow, K; Neuenschwander, M; Gogolin, A; Weise, M; Pfeifer, J; Ziebart, N; Heinemann, U; von Kries, JP; Nazaré, M; Bader, M Structure-Based Design of Xanthine-Benzimidazole Derivatives as Novel and Potent Tryptophan Hydroxylase Inhibitors. J Med Chem65:11126-11149 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Tryptophan 5-hydroxylase 1 |
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| Name: | Tryptophan 5-hydroxylase 1 |
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| Synonyms: | TPH | TPH1 | TPH1_HUMAN | TPRH | TRPH | Tryptophan 5-monooxygenase 1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 50990.64 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1361824 |
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| Residue: | 444 |
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| Sequence: | MIEDNKENKDHSLERGRASLIFSLKNEVGGLIKALKIFQEKHVNLLHIESRKSKRRNSEF
EIFVDCDINREQLNDIFHLLKSHTNVLSVNLPDNFTLKEDGMETVPWFPKKISDLDHCAN
RVLMYGSELDADHPGFKDNVYRKRRKYFADLAMNYKHGDPIPKVEFTEEEIKTWGTVFQE
LNKLYPTHACREYLKNLPLLSKYCGYREDNIPQLEDVSNFLKERTGFSIRPVAGYLSPRD
FLSGLAFRVFHCTQYVRHSSDPFYTPEPDTCHELLGHVPLLAEPSFAQFSQEIGLASLGA
SEEAVQKLATCYFFTVEFGLCKQDGQLRVFGAGLLSSISELKHALSGHAKVKPFDPKITC
KQECLITTFQDVYFVSESFEDAKEKMREFTKTIKRPFGVKYNPYTRSIQILKDTKSITSA
MNELQHDLDVVSDALAKVSRKPSI
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| BDBM357735 |
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| n/a |
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| Name | BDBM357735 |
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| Synonyms: | KM-05-193/(I-209) | US10214530, Example 27 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H22N6O4 |
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| Mol. Mass. | 458.4693 |
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| SMILES | CCCn1c2nc(Cc3nc4cc5OCOc5cc4[nH]3)n(Cc3ccccc3)c2c(=O)[nH]c1=O |
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| Structure | 
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