| Reaction Details |
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 | Report a problem with these data |
| Target | Tryptophan 5-hydroxylase 2 |
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| Ligand | BDBM357760 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2228294 (CHEMBL5141807) |
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| IC50 | 170±n/a nM |
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| Citation |  Specker, E; Matthes, S; Wesolowski, R; Schütz, A; Grohmann, M; Alenina, N; Pleimes, D; Mallow, K; Neuenschwander, M; Gogolin, A; Weise, M; Pfeifer, J; Ziebart, N; Heinemann, U; von Kries, JP; Nazaré, M; Bader, M Structure-Based Design of Xanthine-Benzimidazole Derivatives as Novel and Potent Tryptophan Hydroxylase Inhibitors. J Med Chem65:11126-11149 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Tryptophan 5-hydroxylase 2 |
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| Name: | Tryptophan 5-hydroxylase 2 |
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| Synonyms: | NTPH | TPH2 | TPH2_HUMAN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 56055.12 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_487490 |
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| Residue: | 490 |
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| Sequence: | MQPAMMMFSSKYWARRGFSLDSAVPEEHQLLGSSTLNKPNSGKNDDKGNKGSSKREAATE
SGKTAVVFSLKNEVGGLVKALRLFQEKRVNMVHIESRKSRRRSSEVEIFVDCECGKTEFN
ELIQLLKFQTTIVTLNPPENIWTEEEELEDVPWFPRKISELDKCSHRVLMYGSELDADHP
GFKDNVYRQRRKYFVDVAMGYKYGQPIPRVEYTEEETKTWGVVFRELSKLYPTHACREYL
KNFPLLTKYCGYREDNVPQLEDVSMFLKERSGFTVRPVAGYLSPRDFLAGLAYRVFHCTQ
YIRHGSDPLYTPEPDTCHELLGHVPLLADPKFAQFSQEIGLASLGASDEDVQKLATCYFF
TIEFGLCKQEGQLRAYGAGLLSSIGELKHALSDKACVKAFDPKTTCLQECLITTFQEAYF
VSESFEEAKEKMRDFAKSITRPFSVYFNPYTQSIEILKDTRSIENVVQDLRSDLNTVCDA
LNKMNQYLGI
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| BDBM357760 |
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| n/a |
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| Name | BDBM357760 |
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| Synonyms: | KM-05-50/(I-4) | US10214530, Example 4 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H25N7O3 |
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| Mol. Mass. | 471.5111 |
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| SMILES | Cn1c2nc(Cc3nc4cc(ccc4[nH]3)N3CCOCC3)n(Cc3ccccc3)c2c(=O)[nH]c1=O |
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| Structure | 
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