| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Tryptophan 5-hydroxylase 2 |
|---|
| Ligand | BDBM357761 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_2228294 (CHEMBL5141807) |
|---|
| IC50 | 690±n/a nM |
|---|
| Citation |  Specker, E; Matthes, S; Wesolowski, R; Schütz, A; Grohmann, M; Alenina, N; Pleimes, D; Mallow, K; Neuenschwander, M; Gogolin, A; Weise, M; Pfeifer, J; Ziebart, N; Heinemann, U; von Kries, JP; Nazaré, M; Bader, M Structure-Based Design of Xanthine-Benzimidazole Derivatives as Novel and Potent Tryptophan Hydroxylase Inhibitors. J Med Chem65:11126-11149 (2022) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Tryptophan 5-hydroxylase 2 |
|---|
| Name: | Tryptophan 5-hydroxylase 2 |
|---|
| Synonyms: | NTPH | TPH2 | TPH2_HUMAN |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 56055.12 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_487490 |
|---|
| Residue: | 490 |
|---|
| Sequence: | MQPAMMMFSSKYWARRGFSLDSAVPEEHQLLGSSTLNKPNSGKNDDKGNKGSSKREAATE
SGKTAVVFSLKNEVGGLVKALRLFQEKRVNMVHIESRKSRRRSSEVEIFVDCECGKTEFN
ELIQLLKFQTTIVTLNPPENIWTEEEELEDVPWFPRKISELDKCSHRVLMYGSELDADHP
GFKDNVYRQRRKYFVDVAMGYKYGQPIPRVEYTEEETKTWGVVFRELSKLYPTHACREYL
KNFPLLTKYCGYREDNVPQLEDVSMFLKERSGFTVRPVAGYLSPRDFLAGLAYRVFHCTQ
YIRHGSDPLYTPEPDTCHELLGHVPLLADPKFAQFSQEIGLASLGASDEDVQKLATCYFF
TIEFGLCKQEGQLRAYGAGLLSSIGELKHALSDKACVKAFDPKTTCLQECLITTFQEAYF
VSESFEEAKEKMRDFAKSITRPFSVYFNPYTQSIEILKDTRSIENVVQDLRSDLNTVCDA
LNKMNQYLGI
|
|
|
|---|
| BDBM357761 |
|---|
| n/a |
|---|
| Name | BDBM357761 |
|---|
| Synonyms: | KM-05-55 Fr10-12/(l-6) | US10214530, Example 6 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C21H19N7O2 |
|---|
| Mol. Mass. | 401.4213 |
|---|
| SMILES | Cn1c2nc(Cc3nc4ccc(N)cc4[nH]3)n(Cc3ccccc3)c2c(=O)[nH]c1=O |
|---|
| Structure | 
|
|---|
Search and Browse
