| Reaction Details |
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 | Report a problem with these data |
| Target | Cytochrome P450 1A2 |
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| Ligand | BDBM394530 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2228717 (CHEMBL5142230) |
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| IC50 | >10000±n/a nM |
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| Citation |  Taylor, AM; Bailey, C; Belmont, LD; Campbell, R; Cantone, N; Côté, A; Crawford, TD; Cummings, R; DeMent, K; Duplessis, M; Flynn, M; Good, AC; Huang, HR; Joshi, S; Leblanc, Y; Murray, J; Nasveschuk, CG; Neiss, A; Poy, F; Romero, FA; Sandy, P; Tang, Y; Tsui, V; Zawadzke, L; Sims, RJ; Audia, JE; Bellon, SF; Magnuson, SR; Albrecht, BK; Cochran, AG GNE-064: A Potent, Selective, and Orally Bioavailable Chemical Probe for the Bromodomains of SMARCA2 and SMARCA4 and the Fifth Bromodomain of PBRM1. J Med Chem65:11177-11186 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cytochrome P450 1A2 |
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| Name: | Cytochrome P450 1A2 |
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| Synonyms: | CP1A2_HUMAN | CYP1A2 | CYPIA2 | Cholesterol 25-hydroxylase | Cytochrome P(3)450 | Cytochrome P450 1A | Cytochrome P450 1A2 (CYP1A2) | Cytochrome P450 4 | Cytochrome P450-P3 |
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| Type: | Enzyme |
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| Mol. Mass.: | 58423.38 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P05177 |
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| Residue: | 516 |
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| Sequence: | MALSQSVPFSATELLLASAIFCLVFWVLKGLRPRVPKGLKSPPEPWGWPLLGHVLTLGKN
PHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDG
QSLTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELM
AGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETASSGNPLDFFP
ILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGN
LIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLS
DRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPEL
WEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLE
FSVPPGVKVDLTPIYGLTMKHARCEHVQARLRFSIN
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| BDBM394530 |
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| n/a |
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| Name | BDBM394530 |
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| Synonyms: | (R)-1-(4-(3-amino-6-(2- | US10308614, Example 131 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H21N5O2 |
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| Mol. Mass. | 327.3809 |
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| SMILES | C[C@@H]1CN(CCN1C(C)=O)c1cc(nnc1N)-c1ccccc1O |r| |
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| Structure | 
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