Ki Summary

Reaction Details

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Target

Motilin receptor

Ligand

BDBM50599722

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_2231450 (CHEMBL5145222)

EC50

>10000±n/a nM

Citation

Toda, N; Shida, T; Takano, R; Katagiri, T; Hirouchi, M; Abe, M; Soma, K; Nakagami, Y; Yamazaki, M Discovery of DS-3801b, a non-macrolide GPR38 agonist with N-methylanilide structure. Bioorg Med Chem Lett59:0 (2022) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Motilin receptor

Name:

Motilin receptor

Synonyms:

Type:

PROTEIN

Mol. Mass.:

45365.95

Organism:

Homo sapiens (Human)

Description:

ChEMBL_122664

Residue:

412

Sequence:

MGSPWNGSDGPEGAREPPWPALPPCDERRCSPFPLGALVPVTAVCLCLFVVGVSGNVVTV
MLIGRYRDMRTTTNLYLGSMAVSDLLILLGLPFDLYRLWRSRPWVFGPLLCRLSLYVGEG
CTYATLLHMTALSVERYLAICRPLRARVLVTRRRVRALIAVLWAVALLSAGPFLFLVGVE
QDPGISVVPGLNGTARIASSPLASSPPLWLSRAPPPSPPSGPETAEAAALFSRECRPSPA
QLGALRVMLWVTTAYFFLPFLCLSILYGLIGRELWSSRRPLRGPAASGRERGHRQTVRVL
LVVVLAFIICWLPFHVGRIIYINTEDSRMMYFSQYFNIVALQLFYLSASINPILYNLISK
KYRAAAFKLLLARKSRPRGFHRSRDTAGEVAGDTGGDTVGYTETSANVKTMG

BDBM50599722

n/a

Name

BDBM50599722

Synonyms:

CHEMBL5187975

Type

Small organic molecule

Emp. Form.

C25H32FN3O2

Mol. Mass.

425.5389

SMILES

C[C@H]1CN(Cc2ccc(NC(=O)[C@H]3CC[C@@H](CC3)Oc3ccc(F)cc3)cc2)CCN1 |r,wU:1.0,12.11,wD:15.18,(-2.66,2.7,;-4,1.93,;-4,.39,;-5.33,-.38,;-5.33,-1.92,;-4,-2.69,;-2.66,-1.92,;-1.33,-2.69,;-1.33,-4.23,;-0,-5,;1.33,-4.23,;2.67,-5,;1.33,-2.69,;-0,-1.92,;-0,-.38,;1.33,.39,;2.67,-.38,;2.67,-1.92,;1.33,1.93,;2.67,2.7,;2.67,4.24,;4,5,;5.33,4.23,;6.66,5,;5.33,2.7,;4.01,1.92,;-2.66,-5,;-4,-4.24,;-6.66,.39,;-6.66,1.93,;-5.33,2.7,)|

Structure