Ki Summary

Reaction Details

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Target

Motilin receptor

Ligand

BDBM50599732

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_2231450 (CHEMBL5145222)

EC50

7.5±n/a nM

Citation

Toda, N; Shida, T; Takano, R; Katagiri, T; Hirouchi, M; Abe, M; Soma, K; Nakagami, Y; Yamazaki, M Discovery of DS-3801b, a non-macrolide GPR38 agonist with N-methylanilide structure. Bioorg Med Chem Lett59:0 (2022) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Motilin receptor

Name:

Motilin receptor

Synonyms:

Type:

PROTEIN

Mol. Mass.:

45365.95

Organism:

Homo sapiens (Human)

Description:

ChEMBL_122664

Residue:

412

Sequence:

MGSPWNGSDGPEGAREPPWPALPPCDERRCSPFPLGALVPVTAVCLCLFVVGVSGNVVTV
MLIGRYRDMRTTTNLYLGSMAVSDLLILLGLPFDLYRLWRSRPWVFGPLLCRLSLYVGEG
CTYATLLHMTALSVERYLAICRPLRARVLVTRRRVRALIAVLWAVALLSAGPFLFLVGVE
QDPGISVVPGLNGTARIASSPLASSPPLWLSRAPPPSPPSGPETAEAAALFSRECRPSPA
QLGALRVMLWVTTAYFFLPFLCLSILYGLIGRELWSSRRPLRGPAASGRERGHRQTVRVL
LVVVLAFIICWLPFHVGRIIYINTEDSRMMYFSQYFNIVALQLFYLSASINPILYNLISK
KYRAAAFKLLLARKSRPRGFHRSRDTAGEVAGDTGGDTVGYTETSANVKTMG

BDBM50599732

n/a

Name

BDBM50599732

Synonyms:

CHEMBL5190786

Type

Small organic molecule

Emp. Form.

C28H38FN3O3

Mol. Mass.

483.618

SMILES

C[C@H]1CN(Cc2ccc(cc2C)N(C)C(=O)[C@H]2CC[C@@H](CC2)Oc2ccc(F)c(CO)c2)CCN1 |r,wU:16.16,1.0,wD:19.23,(-3.33,3.47,;-4.67,2.7,;-4.67,1.16,;-6,.39,;-6,-1.15,;-4.67,-1.92,;-3.33,-1.15,;-2,-1.92,;-2,-3.46,;-3.33,-4.23,;-4.67,-3.47,;-6,-4.24,;-.67,-4.23,;-.67,-5.77,;.66,-3.46,;2,-4.23,;.66,-1.92,;-.67,-1.15,;-.67,.39,;.66,1.16,;2,.39,;2,-1.15,;.66,2.7,;2,3.47,;2,5.01,;3.33,5.77,;4.66,5,;6,5.77,;4.67,3.47,;6,2.7,;7.33,3.47,;3.34,2.69,;-7.33,1.16,;-7.33,2.7,;-6,3.47,)|

Structure