Ki Summary

Reaction Details

Report a problem with these data

Target

Motilin receptor

Ligand

BDBM50599736

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_2231450 (CHEMBL5145222)

EC50

4.7±n/a nM

Citation

Toda, N; Shida, T; Takano, R; Katagiri, T; Hirouchi, M; Abe, M; Soma, K; Nakagami, Y; Yamazaki, M Discovery of DS-3801b, a non-macrolide GPR38 agonist with N-methylanilide structure. Bioorg Med Chem Lett59:0 (2022) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Motilin receptor

Name:

Motilin receptor

Synonyms:

Type:

PROTEIN

Mol. Mass.:

45365.95

Organism:

Homo sapiens (Human)

Description:

ChEMBL_122664

Residue:

412

Sequence:

MGSPWNGSDGPEGAREPPWPALPPCDERRCSPFPLGALVPVTAVCLCLFVVGVSGNVVTV
MLIGRYRDMRTTTNLYLGSMAVSDLLILLGLPFDLYRLWRSRPWVFGPLLCRLSLYVGEG
CTYATLLHMTALSVERYLAICRPLRARVLVTRRRVRALIAVLWAVALLSAGPFLFLVGVE
QDPGISVVPGLNGTARIASSPLASSPPLWLSRAPPPSPPSGPETAEAAALFSRECRPSPA
QLGALRVMLWVTTAYFFLPFLCLSILYGLIGRELWSSRRPLRGPAASGRERGHRQTVRVL
LVVVLAFIICWLPFHVGRIIYINTEDSRMMYFSQYFNIVALQLFYLSASINPILYNLISK
KYRAAAFKLLLARKSRPRGFHRSRDTAGEVAGDTGGDTVGYTETSANVKTMG

BDBM50599736

n/a

Name

BDBM50599736

Synonyms:

CHEMBL5196982

Type

Small organic molecule

Emp. Form.

C29H41N3O3

Mol. Mass.

479.6541

SMILES

C[C@H]1CN(Cc2ccc(cc2C)N(C)C(=O)[C@H]2CC[C@@H](CC2)Oc2cccc(CCO)c2)CCN1 |r,wU:16.16,1.0,wD:19.23,(-4,3.47,;-5.33,2.7,;-5.33,1.16,;-6.67,.39,;-6.67,-1.15,;-5.33,-1.92,;-4,-1.15,;-2.67,-1.92,;-2.67,-3.46,;-3.99,-4.23,;-5.33,-3.47,;-6.67,-4.24,;-1.34,-4.23,;-1.34,-5.77,;-0,-3.46,;1.33,-4.23,;-0,-1.92,;-1.34,-1.15,;-1.34,.39,;-0,1.16,;1.33,.39,;1.33,-1.15,;-0,2.7,;1.33,3.47,;1.33,5.01,;2.66,5.77,;4,5,;4,3.47,;5.33,2.7,;6.67,3.47,;8,2.7,;2.67,2.69,;-8,1.16,;-8,2.7,;-6.67,3.47,)|

Structure