Ki Summary

Reaction Details

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Target

Motilin receptor

Ligand

BDBM50599738

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_2231450 (CHEMBL5145222)

EC50

1.6±n/a nM

Citation

Toda, N; Shida, T; Takano, R; Katagiri, T; Hirouchi, M; Abe, M; Soma, K; Nakagami, Y; Yamazaki, M Discovery of DS-3801b, a non-macrolide GPR38 agonist with N-methylanilide structure. Bioorg Med Chem Lett59:0 (2022) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Motilin receptor

Name:

Motilin receptor

Synonyms:

Type:

PROTEIN

Mol. Mass.:

45365.95

Organism:

Homo sapiens (Human)

Description:

ChEMBL_122664

Residue:

412

Sequence:

MGSPWNGSDGPEGAREPPWPALPPCDERRCSPFPLGALVPVTAVCLCLFVVGVSGNVVTV
MLIGRYRDMRTTTNLYLGSMAVSDLLILLGLPFDLYRLWRSRPWVFGPLLCRLSLYVGEG
CTYATLLHMTALSVERYLAICRPLRARVLVTRRRVRALIAVLWAVALLSAGPFLFLVGVE
QDPGISVVPGLNGTARIASSPLASSPPLWLSRAPPPSPPSGPETAEAAALFSRECRPSPA
QLGALRVMLWVTTAYFFLPFLCLSILYGLIGRELWSSRRPLRGPAASGRERGHRQTVRVL
LVVVLAFIICWLPFHVGRIIYINTEDSRMMYFSQYFNIVALQLFYLSASINPILYNLISK
KYRAAAFKLLLARKSRPRGFHRSRDTAGEVAGDTGGDTVGYTETSANVKTMG

BDBM50599738

n/a

Name

BDBM50599738

Synonyms:

CHEMBL5192530

Type

Small organic molecule

Emp. Form.

C32H46N4O3

Mol. Mass.

534.7326

SMILES

CC(C)NC(=O)Cc1cccc(O[C@H]2CC[C@@H](CC2)C(=O)N(C)c2ccc(CN3CCN[C@@H](C)C3)c(C)c2)c1 |r,wU:16.19,32.33,wD:13.12,(9.33,2.7,;8,3.47,;8,5.01,;6.67,2.7,;5.33,3.47,;5.33,5.01,;4,2.7,;2.67,3.47,;2.66,5,;1.33,5.77,;-0,5.01,;-0,3.47,;-1.34,2.7,;-1.34,1.16,;-2.67,.39,;-2.67,-1.15,;-1.34,-1.92,;-0,-1.15,;-0,.39,;-1.34,-3.46,;-0,-4.23,;-2.67,-4.23,;-2.67,-5.77,;-4,-3.46,;-4,-1.92,;-5.33,-1.15,;-6.67,-1.92,;-8,-1.15,;-8,.39,;-9.33,1.16,;-9.33,2.7,;-8,3.47,;-6.67,2.7,;-5.33,3.47,;-6.67,1.16,;-6.67,-3.47,;-8,-4.24,;-5.33,-4.23,;1.34,2.69,)|

Structure