| Reaction Details |
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 | Report a problem with these data |
| Target | Sodium- and chloride-dependent glycine transporter 1 |
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| Ligand | BDBM50178425 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_339708 (CHEMBL867170) |
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| IC50 | 2800±n/a nM |
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| Citation |  Thomson, CG; Duncan, K; Fletcher, SR; Huscroft, IT; Pillai, G; Raubo, P; Smith, AJ; Stead, D Sarcosine based indandione hGlyT1 inhibitors. Bioorg Med Chem Lett16:1388-91 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Sodium- and chloride-dependent glycine transporter 1 |
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| Name: | Sodium- and chloride-dependent glycine transporter 1 |
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| Synonyms: | GlyT-1 | GlyT1 | Glycine Transporters (GlyT1c) | Glycine transporter 1 | SC6A9_HUMAN | SLC6A9 | Sodium- and chloride-dependent glycine transporter 1 | Sodium- and chloride-dependent glycine transporter 1 (GlyT1) | Sodium- and chloride-dependent glycine transporter 1 (GlyT1c) | Sodium-and chloride-dependent glycine transporter 1 (GlyT-1c) | Solute carrier family 6 member 9 |
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| Type: | Enzyme |
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| Mol. Mass.: | 78270.54 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P48067 |
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| Residue: | 706 |
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| Sequence: | MSGGDTRAAIARPRMAAAHGPVAPSSPEQVTLLPVQRSFFLPPFSGATPSTSLAESVLKV
WHGAYNSGLLPQLMAQHSLAMAQNGAVPSEATKRDQNLKRGNWGNQIEFVLTSVGYAVGL
GNVWRFPYLCYRNGGGAFMFPYFIMLIFCGIPLFFMELSFGQFASQGCLGVWRISPMFKG
VGYGMMVVSTYIGIYYNVVICIAFYYFFSSMTHVLPWAYCNNPWNTHDCAGVLDASNLTN
GSRPAALPSNLSHLLNHSLQRTSPSEEYWRLYVLKLSDDIGNFGEVRLPLLGCLGVSWLV
VFLCLIRGVKSSGKVVYFTATFPYVVLTILFVRGVTLEGAFDGIMYYLTPQWDKILEAKV
WGDAASQIFYSLGCAWGGLITMASYNKFHNNCYRDSVIISITNCATSVYAGFVIFSILGF
MANHLGVDVSRVADHGPGLAFVAYPEALTLLPISPLWSLLFFFMLILLGLGTQFCLLETL
VTAIVDEVGNEWILQKKTYVTLGVAVAGFLLGIPLTSQAGIYWLLLMDNYAASFSLVVIS
CIMCVAIMYIYGHRNYFQDIQMMLGFPPPLFFQICWRFVSPAIIFFILVFTVIQYQPITY
NHYQYPGWAVAIGFLMALSSVLCIPLYAMFRLCRTDGDTLLQRLKNATKPSRDWGPALLE
HRTGRYAPTIAPSPEDGFEVQPLHPDKAQIPIVGSNGSSRLQDSRI
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| BDBM50178425 |
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| n/a |
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| Name | BDBM50178425 |
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| Synonyms: | 2-((3-(1,3-dioxo-2-phenyl-2,3-dihydro-1H-inden-2-yl)propyl)(methyl)amino)acetic acid | CHEMBL206129 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H21NO4 |
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| Mol. Mass. | 351.3957 |
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| SMILES | CN(CCCC1(C(=O)c2ccccc2C1=O)c1ccccc1)CC(O)=O |
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| Structure | 
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