| Reaction Details |
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 | Report a problem with these data |
| Target | NAD-dependent protein deacetylase sirtuin-2 |
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| Ligand | BDBM50178767 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_325279 (CHEMBL859690) |
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| IC50 | 24800±n/a nM |
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| Citation |  Napper, AD; Hixon, J; McDonagh, T; Keavey, K; Pons, JF; Barker, J; Yau, WT; Amouzegh, P; Flegg, A; Hamelin, E; Thomas, RJ; Kates, M; Jones, S; Navia, MA; Saunders, JO; DiStefano, PS; Curtis, R Discovery of indoles as potent and selective inhibitors of the deacetylase SIRT1. J Med Chem48:8045-54 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| NAD-dependent protein deacetylase sirtuin-2 |
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| Name: | NAD-dependent protein deacetylase sirtuin-2 |
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| Synonyms: | NAD-Dependent Deacetylase Sirtuin-2 | NAD-dependent deacetylase sirtuin 2 | NAD-dependent deacetylase sirtuin 3 | NAD-dependent protein deacetylase sirtuin-2 (SIRT2) | SIR2-like | SIR2-like protein 2 | SIR2L | SIR2L2 | SIR2_HUMAN | SIRT2 | Sirtuin 2 (SIRT2) |
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| Type: | Hydrolase |
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| Mol. Mass.: | 43172.62 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 389 |
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| Sequence: | MAEPDPSHPLETQAGKVQEAQDSDSDSEGGAAGGEADMDFLRNLFSQTLSLGSQKERLLD
ELTLEGVARYMQSERCRRVICLVGAGISTSAGIPDFRSPSTGLYDNLEKYHLPYPEAIFE
ISYFKKHPEPFFALAKELYPGQFKPTICHYFMRLLKDKGLLLRCYTQNIDTLERIAGLEQ
EDLVEAHGTFYTSHCVSASCRHEYPLSWMKEKIFSEVTPKCEDCQSLVKPDIVFFGESLP
ARFFSCMQSDFLKVDLLLVMGTSLQVQPFASLISKAPLSTPRLLINKEKAGQSDPFLGMI
MGLGGGMDFDSKKAYRDVAWLGECDQGCLALAELLGWKKELEDLVRREHASIDAQSGAGV
PNPSTSASPKKSPPPAKDEARTTEREKPQ
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| BDBM50178767 |
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| n/a |
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| Name | BDBM50178767 |
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| Synonyms: | 2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide | CHEMBL112265 |
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| Type | Small organic molecule |
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| Emp. Form. | C13H14N2O |
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| Mol. Mass. | 214.2631 |
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| SMILES | NC(=O)C1CCCc2c1[nH]c1ccccc21 |
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| Structure | 
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