Reaction Details |
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Target | NAD-dependent protein deacetylase sirtuin-3, mitochondrial |
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Ligand | BDBM50178766 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_325280 (CHEMBL859691) |
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IC50 | >100000±n/a nM |
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Citation | Napper, AD; Hixon, J; McDonagh, T; Keavey, K; Pons, JF; Barker, J; Yau, WT; Amouzegh, P; Flegg, A; Hamelin, E; Thomas, RJ; Kates, M; Jones, S; Navia, MA; Saunders, JO; DiStefano, PS; Curtis, R Discovery of indoles as potent and selective inhibitors of the deacetylase SIRT1. J Med Chem48:8045-54 (2005) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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NAD-dependent protein deacetylase sirtuin-3, mitochondrial |
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Name: | NAD-dependent protein deacetylase sirtuin-3, mitochondrial |
Synonyms: | NAD-dependent deacetylase sirtuin 3 | NAD-dependent protein deacetylase sirtuin-3 (SIRT3) | SIR2L3 | SIR3_HUMAN | SIRT3 |
Type: | Protein |
Mol. Mass.: | 43582.69 |
Organism: | Homo sapiens (Human) |
Description: | Q9NTG7 |
Residue: | 399 |
Sequence: | MAFWGWRAAAALRLWGRVVERVEAGGGVGPFQACGCRLVLGGRDDVSAGLRGSHGARGEP
LDPARPLQRPPRPEVPRAFRRQPRAAAPSFFFSSIKGGRRSISFSVGASSVVGSGGSSDK
GKLSLQDVAELIRARACQRVVVMVGAGISTPSGIPDFRSPGSGLYSNLQQYDLPYPEAIF
ELPFFFHNPKPFFTLAKELYPGNYKPNVTHYFLRLLHDKGLLLRLYTQNIDGLERVSGIP
ASKLVEAHGTFASATCTVCQRPFPGEDIRADVMADRVPRCPVCTGVVKPDIVFFGEPLPQ
RFLLHVVDFPMADLLLILGTSLEVEPFASLTEAVRSSVPRLLINRDLVGPLAWHPRSRDV
AQLGDVVHGVESLVELLGWTEEMRDLVQRETGKLDGPDK
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BDBM50178766 |
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n/a |
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Name | BDBM50178766 |
Synonyms: | 2-chloro-5,6,7,8,9,10-hexahydrocyclohepta[b]indole-6-carboxamide | 2-chloro-5,6,7,8,9,10-hexahydrocyclohepta[b]indole-6-carboxylic acid amide | CHEMBL446446 |
Type | Small organic molecule |
Emp. Form. | C14H15ClN2O |
Mol. Mass. | 262.735 |
SMILES | NC(=O)C1CCCCc2c1[nH]c1ccc(Cl)cc21 |
Structure |
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