| Reaction Details |
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 | Report a problem with these data |
| Target | RuvB-like 2 |
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| Ligand | BDBM50600243 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2233419 (CHEMBL5147191) |
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| IC50 | >66000±n/a nM |
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| Citation |  Zhang, G; Wang, F; Li, S; Cheng, KW; Zhu, Y; Huo, R; Abdukirim, E; Kang, G; Chou, TF Discovery of small-molecule inhibitors of RUVBL1/2 ATPase. Bioorg Med Chem62:0 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| RuvB-like 2 |
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| Name: | RuvB-like 2 |
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| Synonyms: | 3.6.4.12 | 48 kDa TATA box-binding protein-interacting protein | 48 kDa TBP-interacting protein | 51 kDa erythrocyte cytosolic protein | ECP-51 | INO80 complex subunit J | INO80J | RUVB2_HUMAN | RUVBL2 | Repressing pontin 52 | Reptin 52 | TAP54-beta | TIP48 | TIP49B | TIP60-associated protein 54-beta |
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| Type: | PROTEIN |
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| Mol. Mass.: | 51149.94 |
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| Organism: | Homo sapiens |
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| Description: | ChEMBL_104584 |
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| Residue: | 463 |
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| Sequence: | MATVTATTKVPEIRDVTRIERIGAHSHIRGLGLDDALEPRQASQGMVGQLAARRAAGVVL
EMIREGKIAGRAVLIAGQPGTGKTAIAMGMAQALGPDTPFTAIAGSEIFSLEMSKTEALT
QAFRRSIGVRIKEETEIIEGEVVEIQIDRPATGTGSKVGKLTLKTTEMETIYDLGTKMIE
SLTKDKVQAGDVITIDKATGKISKLGRSFTRARDYDAMGSQTKFVQCPDGELQKRKEVVH
TVSLHEIDVINSRTQGFLALFSGDTGEIKSEVREQINAKVAEWREEGKAEIIPGVLFIDE
VHMLDIESFSFLNRALESDMAPVLIMATNRGITRIRGTSYQSPHGIPIDLLDRLLIVSTT
PYSEKDTKQILRIRCEEEDVEMSEDAYTVLTRIGLETSLRYAIQLITAASLVCRKRKGTE
VQVDDIKRVYSLFLDESRSTQYMKEYQDAFLFNELKGETMDTS
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| BDBM50600243 |
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| n/a |
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| Name | BDBM50600243 |
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| Synonyms: | CHEMBL5196000 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H25ClF3N5O |
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| Mol. Mass. | 527.969 |
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| SMILES | Cc1nc2c(cnn2c(C)c1Cc1ccc(Cl)cc1)C(=O)N1CCN(CC1)c1cccc(c1)C(F)(F)F |
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| Structure | 
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